Zhongping LuResearch Professor of Biochemistry and Molecular Medicine
Office Phone: 202-745-5000 ext. 5851
Department: Biochemistry and Molecular Medicine
- MSc, Shanghai Jiao Tong University School of Medicine, 2002
- PhD, Shanghai Jiao Tong University School of Medicine, 2005
Dr. Lu’s laboratory focuses on acetyl modification of mitochondrial proteins and its role in diseases and stresses. The emerging evidence support the importance of acetylation and deacetylation modifications of mitochondrial proteins in regulating mitochondrial activities, cell function, and pathophysiology of numerous diseases. Using proteomic approach, he and his colleagues have identified new targets of a mitochondrial deacetylase – SIRT3. His group is actively exploring the role of these modified proteins in drug-induced hepatotoxicity, alcoholic hepatitis and metabolic diseases.
View publications by this faculty member from January 1, 2013 - present
Bradley Webster, Iain Scott, Kim Han, Jian-Hua Li, Zhongping Lu, Mark Stevens, Daniela Malide, Yong Chen, Leigh Samsel, Patricia Connelly, Mathew Daniels, J. Philip McCoy, Christian Combs, Marjan Gucek, and Michael Sack. Restricted mitochondrial protein acetylation initiates mitochondrial autophagy. Journal of Cell Science, 2013 Sep 4.
Bradley R. Webster, Zhongping Lu, Michael N. Sack, Iain Scott. The role of sirtuins in modulating redox stressors. Free Radical Biology and Medicine, 2012; 52(2):281-290.
Zhongping Lu, Mohammed Bourdi, Jian H Li, Angel M Aponte, David B Lombard, Marjan Gucek, Lance R Pohl, Michael N Sack. SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. EMBO reports, 2011;12(8):840-6.
Jianjun Bao, Iain Scott, Liyan Pang, Zhongping Lu, Christopher C Dimond, David Gius, Michael Neil Sack. SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radical Biology and Medicine, 2010; 48(7):1230-7
Jianjun Bao, Zhongping Lu, Michael N. Sack. Characterization of the Murine SIRT3 Mitochondrial Localization Sequence and Comparison of Mitochondrial Enrichment and Deacetylase Activity of Long and Short SIRT3 Isoforms. Journal of Cellular Biochemistry, 2010; 110(1):238-47
Zhongping Lu, Iain Scott, Bradley Webster, Michael N. Sack. The emerging characterization of mitochondrial function and cardiovascular biology. Circulation Research, 2009; 105(9):830-41
Zhongping Lu, Michael N. Sack. ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial uncoupling protein 3. The Journal of Biological Chemistry, 2008; 283(34):23410-8.
Edward G. Lynn, Zhongping Lu, Diane Minerbi, Michael N. Sack. The regulation, control and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxia. Antioxidants & Redox Signaling, 2007; 9(9): 1353-61.
Zhong-Ping Lu, Zhong-Liang Ju, Jian Sun,et al. Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. Biochem Biophys Res Commun, 2005; 330:204-209
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the healthcare related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.