Senior Associate Dean for Research
Vivian Gill Distinguished Research Professor
Vice President for Research
Professor of Anatomy and Cell Biology
Office Phone: 202-994-6988
Department: Anatomy and Cell Biology
HonorsScience Research Council Grant (1977-80)
Alfred P. Sloan Fellow (1989-91)
Charles Judson Herrick Award, American Association of Anatomists (1989)
John S. Diekhoff Award for Excellence in Graduate Teaching (1994)
Jacob Javits Neuroscience Award (2001)
Outstanding Faculty Award CWRU School of Medicine (2003)
Myelin Repair Foundation President’s Award (2012)
National Academy of Inventors Fellow (2013)
Current Research ThemesNeural Development/Stem Cells (Longstanding research area)
- Understand cellular and molecular control of nervous system glial specification
- Identify molecules that regulate glial cell proliferation and migration.
- Utilize adult neural progenitor cells to enhance repair
- Characterize human neural progenitor cells
- Characterize cellular origins of neural tumors
- Identify novel therapeutic targets to control cell proliferation, death and migration of neural cells
- Utilize molecules important in glial development to facilitate spinal cord repair
- Develop neural and non-neural stem cell approaches to modulate spinal cord injury responses.
View publications by this faculty member.
Caprariello AV, Miller RH. The power and pitfalls of strategies for selective ablation of oligodendrocytes in the vertebrate CNS. J. Translational Med. (Accepted)
Guyuron B, Miller RH. Electron Microscopic and Proteomic Comparison of Terminal Branches of the Trigeminal Nerve on Patients With and Without Migraine Headaches. Plastic and Reconstructive Surgery. 2014. (Accepted).
Bai L, Delia B, Hecker J, Miller RH. Stem cell therapies for brain disorders. Textbook for Neural Repair and Rehabilitation. Cambridge University Press. May 2014.
Miller RH. Glial development and axon regeneration. Textbook for Neural Repair and Rehabilitation. Cambridge University Press. May 2014.
Tilot AK, Gaugler MK, Yu Q, Romigh T, Yu W, Miller RH, Frazier TW 2nd, Eng C. Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production. Hum Mol Genet. 2014 Jun 15;23(12):3212-27. PMID: 24470394
Jantzie LL, Getsy PM, Firl DJ, Wilson CG, Miller RH, Robinson R. Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury. Mol Cell Neurosci. 2014 Jun 28. PMID: 24983520
Luo F, Burke K, Kantor C, Miller RH, Yang Y. Cyclin dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3? signaling. J. Neurosci. 2014 Jul 30;34(31):10415-29. PMID: 25080600.
Ravikumar M, Sunil S, Black J, Barkauskas DS, Haung AY, Miller RH, Selkirk SM, Capadona JR. The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes. Biomaterials. 2014 Sep;35(28):8049-64. PMID: 24973296
Bai L, Hecker J, Kerstetter-Fogle AE, Miller RH. Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis. Neurosci Bull. 2013 Apr;29(2):239-50. PMID: 23471865
Yang Y, Wang H, Zhang J, Herrup K, Bibb JA, Lu R, Miller RH. Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation. Developmental Biology. 2013 Apr 10. PMID: 23583582
Frullano L, Zhu J, Miller RH, Wang Y. Synthesis and characterization of a novel gadolinium-based contrast agent for magnetic resonance imaging of myelination. J. Med Chemistry. 2013 Feb 18. PMID: 23311333
Najm F, Lager A, Zaremba A, Wyatt K, Caprariello A, Factor D, Karl R, Maeda T, Miller RH, and Tesar PJ. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nature Biotechnology. 2013 May;31(5):426-33. PMID: 23584611
Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BD. Activated microglia enhance neurogenesis via trypsinogen secretion. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8714-9. PMID: 23650361
Wu C, Zhu J, Baeslack J, Zaremba A, Hecker J, Kraso J, Matthews PM, Miller RH, Wang Y. Longitudinal PET imaging for monitoring myelin repair in the spinal cord. Ann Neurol. 2013 Jul 1. PMID: 23818306
Fyffe-Maricich SL, Schott A, Karl M, Krasno J, Miller RH. Signaling through ERK1/2 controls myelin thickness during myelin repair in the adult central nervous system. J Neurosci. 2013 Nov 20;33(47):18402-18408. PMID: 24259565
Jantzie LL, Miller RH, Robinson S. Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury. Pediatr Res. 2013 Dec;74(6):658-67. PMID: 24108187
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.