Manjari DimriAssociate Research Professor of Biochemistry and Molecular Medicine
Office Phone: 202-994-7271
Department: Biochemistry and Molecular Medicine
- MBBS, Brd Medical College, India, 1995
My research interest is primarily focused on the search for signaling molecules that might function as cooperative oncogenic lesion with polycomb group (PcG) proteins in breast cancer using global RNAi and expression screening approaches. Another area of focus is to identify and characterize novel microRNAs that control breast cancer progression, particularly metastasis. We are currently performing microRNA profiling studies using a BMI1 and H-RAS transformed human mammary epithelial cell (HMEC) series. Identification of novel PcG-cooperating lesions and metastasis-regulating miRNAs will help us gain a better understanding of breast cancer, and also help find new targets and treatments for cancer therapy.
View publications by this faculty member from January 1, 2013 - present
Sahasrabuddhe AA, Dimri M, Bommi PV, Dimri GP. ?TrCP regulates BMI1 protein turnover via ubiquitination and degradation. Cell Cycle. 2011 Apr 15;10(8):1322-30. Epub 2011 Apr 15. PMID: 21430439
Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle. 2010 Jul 1;9(13):2663-73. PMID: 20543557
Yadav AK, Sahasrabuddhe AA, Dimri M, Bommi PV, Sainger R, Dimri GP. Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain. Mol Cancer. 2010 Jun 22;9:158. PMID: 20569464
Dimri M, Bommi PV, Sahasrabuddhe AA, Khandekar JD, Dimri GP. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. Carcinogenesis. 2010 Mar;31(3):489-95. Epub 2009 Dec 7. PMID:19969553
Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP. Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res. 2007 Nov 1;67(21):10286-95. PMID: 17974970
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the healthcare related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.