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Joshua CorbinProfessor of Pediatrics
Professor of Pharmacology and Physiology (Secondary)
Office Phone: 202-884-6281
- BA, Rutgers University, 1989
- PhD, University of North Carolina, Chapel Hill, 1996
How brain circuitry that regulates specific behaviors emerges from development remains unknown. Research in my laboratory is directed toward addressing how genetic embryonic neurodevelopmental programs pattern development of circuitry of the limbic system: an interconnected set of brain structures that includes the olfactory system, amygdala and hypothalamus. Moreover, we are interested in the consequences of when these processes go awry, resulting in neurodevelopmental disorders such as autism spectrum disorders. To address these questions, using the mouse as a model, we employ a variety of state of the art techniques such as conditional transgenic and optogenetic approaches. From these studies we hope not only to gain greater insight into the neurotypical developing brain, but address core behavioral deficits in prevalent human neurological disorders.
View publications by this faculty member from January 1, 2013 - present
Sokolowski K and Corbin JG (2012). Wired for behaviors: from development to function of innate limbic system circuitry. Front Mol Neurosci. review 5:55
Cocas, L.A.C., Georgala, P. A., Mangin, J.-M., Clegg, J.-M., Kessaris, N., Haydar, T.F., Gallo, V, David J. Price, D.J., and Corbin, J.G. (2011). Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the post-natal limbic system. J. Neurosci., 31, 5313-5324.
Carney R.S.E, Jean-Marie Mangin, J.-M., Hayes, L., Mansfield, K., Sousa, V.H, Fishell, G, Machold, R.P., Ahn, S., Gallo, V. and Corbin, J.G. (2010). Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Development, May, 5;14.
Olmos-Serrano, J-L*., Paluszkiewicz, S*., Martin, B., Kaufmann, W., and Corbin, J.G#., Huntsman, M.M#. (*equal contribution, #co-senior authors). (2010). Defective GABAergic neurotransmision and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of Fragile X Syndrome. J. Neuroscience, 21, 9929-38.
Hirata, T., Li, P-J., Lanuza, G., Cocas, L.A., Huntsman, M.M. and Corbin, J.G. (2009) Identification of distinct telencephalic progenitor pools for excitatory and inhibitory neuronal cell diversity in the amygdala Nature Neuroscience, 12:141-149.
Cocas, L., Miyoshi, G., Carney R.S.E, Sousa, V.H., Hirata, T., Jones, K., Fishell, G., Huntsman, M.M. and Corbin, J.G. (2009) Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. J. Neurosci.,16,15933-46.
Carney, R.S.E, Cocas, L.A., Hirata, T., Mansfield, K., and Corbin, J.G. (2008). Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Cerebral Cortex, Aug 12. [Epub ahead of print]
Carney, RS, Alfonso, TB, Cohen, D., Dai, H., Nery, S., Stoica, B., Slotkin, J., Bregman, B.S., Fishell, G., and Corbin, J.G. (2006). Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. J Neurosci. 26,11562-74.
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the healthcare related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.