Joanna ChmielinskaAssistant Research Professor of Biochemistry and Molecular Medicine
Office Phone: 202-994-3539
Department: Biochemistry and Molecular Medicine
- MS, Nicklaus Copernicus Medical Academy, 1983
- PhD, George Washington University, 1999
Cardiovascular and intestinal tissue injury due to oxidative and nitrosative stress; Central role of Neutral Endopeptidase, critical enzyme for degrading excess substance P in neurogenic inflammation due to the oxidative/nitrosative stress caused by hypomagnesemia; Cardiotoxicity of tyrosine kinase inhibiting chemotherapeutic agents. Immunohistochemical localization of pro-inflammatory proteins in cardiovascular tissue.
View publications by this faculty member from January 1, 2013 - present
Mak, I.-T, Kramer, J.H., Chmielinska, J.J, Spurney, C.F., Weglicki, W.B. The EGFR TKI, erlotinib, causes hypomagnesemia, oxidative stress and cardiac dysfunction: attenuation by substance P-receptor blockade. J. Cardiovasc. Pharmacol. In Press. 2014.
Weglicki, W.B., Mak, I-T., Chmielinska, J.J., Spurney, C.F., Kramer. J.H. Hypomagnesemia-induced neurogenic inflammation and cardiac dysfunction during experimental Mg deficiency. In: Proceedings of the 13th International Magnesium Symposium. Merida, Yucatan, Mexico. In Press. 2014.
Mak, I.-T, Kramer, J.H., Chen X., Chmielinska, J.J, Spurney, C.F., Weglicki, W.B. Mg-supplementation Attenuates Ritonavir-induced Hyperlipidemia, Oxidative Stress and Cardiac Dysfunction in Rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305: R1102–R1111, 2013.
Weglicki, W.B. Kramer, J.H., Spurney, C.F., Chmielinska, J.J., Mak, I.T. The EGFR Tyrosine Kinase Inhibitor Tyrphostin AG-1478 Causes Hypomagnesemia and Cardiac Dysfunction. Can. J. of Physiol. & Pharmacol. (Accepted 1/20/2012) (in press).
Mak I.T. Chmielinska, J.J, Kramer, J.H. Spurney, C.F., Weglicki, W.B. Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: Protection by substance P receptor blockade. Exp. & Clin. Cardiol. 16(4):121-124, 2011.
Weglicki, W.B., Mak, I.-T., Chmielinska, J.J., Tejero-Taldo, M.I., Komarov, A., Kramer, J.H. The role of Magnesium Deficiency in Cardiovascular and Intestinal Inflammation. Magnes. Res. 23(4): 199-206, 2010.
Kramer, J.H., Spurney, C., Iantorno, M., Tziros, C., Mak, I.T., Tejero-Taldo, M.I., Chmielinska, J.J., Komarov, A.M., Weglicki, W.B. Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia in a rodent model. Am. J. Med. Sci. 338: 22-27, 2009.
Weglicki, W.B., Chmielinska, J.J., Tejero-Taldo, M.I., Kramer, J.H., Spurney, C., Viswalingham, K., Lu, B., Mak, I.T. Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia. Magnes. Res. 22: 1-7, 2009.
Mak, I.T., Chmielinska, J.J., Kramer, J.H., Weglicki. W.B. AZT-Induced cardiovascular toxicity - attenuation by Mg-supplementation. Cardiovascular Toxicol. 9(2): 78-85, 2009.
Mak I.T., Kramer J.H., Chmielinska J.J., Khalid M.H., Landgraf K.M., and Weglicki W.B. Inhibition of Neutral Endopeptidase Potentiates Neutrophil Activation during Mg-deficiency in the Rat. Inflamm. Res. 57: 300-305, 2008.
Chmielinska J.J., Tejero-Taldo M.I., Mak I.T., Weglicki W.B. Intestinal and Cardiac Inflammatory Response Shows Enhanced Endotoxin Receptor (CD14) Expression in Magnesium efficiency. Mol. Cell. Biochem. 278: 53-57, 2005.
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the healthcare related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.