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Associate Professor of Pediatrics
Associate Professor of Pharmacology and Physiology (Secondary)
Office Phone: 202-476-3985
- B.S., Xavier University, 2001
- PhD, Indiana University School of Medicine, 2006
Our lab studies the genetic and activity-dependent cues that direct proper wiring in the brain. During development, billions of neurons need to make trillions of synapses in a precise manner to mediate proper sensory perception, behaviors and cognitive processes. In many sensory systems, neurons are organized into topographic maps of space, wherein neighboring neurons monitor adjacent regions of the outside world. In associative centers, maps of different sensory modalities must be brought into register to allow for proper integration. To understand the cellular processes involved in this precise wiring, we utilize anatomical tracing methods, electrophysiology and molecular techniques in transgenic mouse models.
View publications by this faculty member from January 1, 2013 - present
1. Triplett JW, Phan A, Yamada J, Feldheim DA. Alignment of multimodal sensory input in the superior colliculus through a gradient matching mechanism. The Journal of Neuroscience 2012 Apr 11;32(15):5264-71.
2. Triplett JW and Feldheim DA. Eph and ephrin signaling in the formation of topographic maps. Seminars in Cell and Developmental Biology 2012 Feb;23(1):7-15.
3. Brennaman LH, Xuying Z, Guan H, Triplett JW, Brown A, Demyanenko GP, Manis PB, Landmesser L, Maness PF. NCAM interacts with EphrinA/EphA to regulate synaptic development of GABAergic interneurons in prefrontal cortex. Cerebral Cortex 2012 Jan 23 [Epub ahead of print].
4. Triplett JW*, Pfeiffenberger C*, Yamada J, Stafford BK, Sweeney NT, Litke AM, Sher A, Koulakov AA, Feldheim DA. Competition is a driving force in topographic mapping. Proceedings of the National Academy of Sciences 2011 Nov 22;108(47):19060-5.
5. Triplett JW, Owens MT, Yamada J, Lemke G, Cang J, Stryker MP, Feldheim DA. Retinal input instructs alignment of visual topographic maps. Cell 2009 Oct 2;139(1):175-85. a. Highlighted in: Anishchenko A and Feller MB. Go with the flow -- but only in one direction. Neuron 2009 Oct. 29;64(2):152-4.
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.