Faculty Directory

Evan Nadler Evan Nadler
Associate Professor of Surgery
Associate Professor of Pediatrics (Secondary)

Office Phone: 202-476-2151
Email: Email
Department: Surgery

Education

  • B.S., Stanford University, 1991
  • MD, University of Pennsylvania, 1995

Biography

I am a pediatric surgeon and researcher. I recently joined Children's National Medical Center and serves as Co-Director of the Obesity Institute. I perform bariatric surgery on adolescents who meet certain criteria. I work closely with the multidisciplinary team of pediatric specialists in the Obesity Institute.

My basic science research focuses on the liver fibrosis associated with biliary atresia. My clinical and translational science investigates the systems biology of obesity surgery, and the safety and effectiveness of various weight loss procedures in adolescents.

Bibliography

  • Nadler EP, Dickinson EC, Knisely A, Zhang XR, Boyle P, Stolz D, Watkins SC, Ford HR. Expression of Nitric Oxide And Interleukin-12 in Experimental NEC. J Surg Res, 92: 71-77, 2000.
     
  • Nadler EP, Dickinson EC, Stolz D, Alber SM, Watkins SC, Pratt DW, Ford HR.  Scavenging Nitric Oxide Decreases Hepatocellular Injury after Endotoxin Challenge. Am J Physiol, 281: G173-181, 2001.
     
  • Nadler EP, Stanford A, Zhang XR, Schall LC, Alber SM, Watkins SC, Ford HR. Intestinal Cytokine Gene Expression in Infants with Acute NEC:  IL-11 mRNA Expression Inversely Correlates with Extent of Disease.  J Pediatr Surg, 36: 1122-1129, 2001.
     
  • Nadler EP, Youn HA, Ginsburg HB, Ren CJ, Fielding GA. Short-Term Results In 53 U.S. Obese Pediatric Patients Treated With Laparoscopic Adjustable Gastric Banding. J Pediatr Surg. 2007 Jan;42(1):137-41
     
  • Nadler EP, Youn HA, Ren CJ, Fielding GA.  An update on 73 US obese pediatric patients treated with laparoscopic adjustable gastric banding: comorbidity resolution and compliance data. J Pediatr Surg. 2008 Jan;43(1):141-6.
     
  • Nadler EP, Patterson D, Violette S, Weinreb P, Lewis M, Magid MS, Greco MA.  Integrin αvβ6 and Mediators of Extracellular Matrix Deposition are Upregulated in Experimental Biliary Atresia. J Surg Res 2009 Jun;154(1):21-9.
     
  • Nadler EP, Brotman LM, Miyoshi T, Fryer, GE, Weitzman M. The Morbidity in Obese Adolescents who Meet the Adult NIH Criteria for Bariatric Surgery J Pediatr Surg. 2009 Oct;44(10):1869-76.
     
  • Nadler EP, Reddy S, Isenalumhe A, Youn HA, Peck V, Ren CJ, Fielding GA.  Laparoscopic Adjustable Gastric Banding for Morbidly Obese Adolescents Effects Android Fat Loss, Resolution of Comorbidities, and Improved Metabolic Status. J Am Coll Surg 2009 Nov;209(5):638-44.
     
  • Nadler EP, Onyedika E, Li X, Greco MA.  Differential Expression of Hepatic Fibrosis Mediators in Sick and Spontaneously Recovered Mice with Experimental Biliary Atresia. J Surg Res 2010 Apr;159(2):611-7
     
  • Nadler EP, Nwomeh BC, Frederick WA, Hassoun HT, Kingham TP, Krishnaswami S, London JA, Pitt SC, Riviello R, Rogers SO. Academic Needs in Developing Countries: A Survey of the West African College of Surgeons. J Surg Res 2010 May 1;160(1):14-7.

Research

The Role of Transforming Growth Factor-beta (TGF-β) in the Pathogenesis of Experimental Biliary Atresia: the overall goal of this project is to determine the role of in the TGF- β in the pathogenesis of biliary atresia. The approach will be to employ different strategies designed to inhibit TGF- β function and then determine what impact blockade has on the development of the hepatic fibrosis associated with biliary atresia, or on the development of biliary atresia itself.

The Genetic Basis of Weight Loss Surgical Outcomes: A subset of patients fail the most common restrictive weight loss operation (defined as percent excess weight loss < 1 standard deviation below mean percent excess weight loss). The hypothesis is that particular genetic profiles in patients render them unlikely to lose weight after restriction alone.  We believe that genetic variation may be the underlying reason for surgical failures, and that larger genetic contributions to surgical outcomes will be seen in younger populations.  The approach will be to perform genome wide array studies of adult surgical cohorts and then use a candidate gene approach to adolescents undergoing weight loss surgery with the candidate genes being those identified in the adult study.

Publications

View publications by this faculty member.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None