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Edward Seto

Edward Seto

Associate Center Director for Basic Sciences, GW Cancer Center
King Fahd Professor of Cancer Biology
Professor of Biochemistry and Molecular Medicine

Office Phone: 202-994-3156
Email: Email
Department: Biochemistry and Molecular Medicine

Education

  • B.S., University of California, Irvine, 1981
  • Ph.D., University of California, San Francisco, 1990

Biography

Dr. Seto’s laboratory focuses on understanding histone deacetylase, an enzyme that epigenetically regulates how certain genes turn on or off.
His team is developing drugs and chemicals to manipulate the enzyme when it is expressing abnormally high levels in cancer. As the associate center director, Dr. Seto is also developing three basic science research programs that will help the center’s bid for National Cancer Institute designation: cancer biology, immunology/immunotherapy, and microbial oncology.

Grants

Ongoing
R01 CA187040 (PI: Seto)                                                                                                              7/3/2014 - 6/30/2020
NIH/NCI
Targeting SIRT1 in Mantle Cell Lymphoma
The objective of this application is to advance the basic understanding of SIRT1’s biological functions and to clarify whether SIRT1 can be targeted for MCL treatment.

Completed from the past three years
NIH R01 CA169210 (PI: Seto)                                                                                                       7/9/2012 - 4/30/2019
NIH/NCI
The Basic and Translational Implication of SIRT1 and DNMT1 in Cancer
The objective of this application was to understand the interplay of two key enzymes responsible for histone deacetylation and DNA methylation.
 

Awards

King Fahd Professor of Cancer Biology
 

Teaching

Academic year 2018-19:

BMSC 8210
Genes to Cells

CANC 8221
The Basic Science of Oncology

CANC 8222
Molecular Oncology and Cancer Epigenetics

BIOC 6222
Biochemical Genetics and Medicine
 

 

Research

The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of gene transcription and are indispensable in numerous eukaryotic biological processes involving chromatin.

Centers and Institutes

GW Cancer Center

Programs

  • GW Cancer Center

Publications

View publications by this faculty member from January 1, 2013 - present

Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None