Faculty Directory

Back to Search Results
 
Dominic Raj Dominic Raj
Professor of Medicine

Office Phone: 202-741-2233
Email: Email
Department: Medicine

Education

  • B.Sc, St. Hindu College, 1977
  • MBBS, Madurai Med Coll, 1982
  • MD, Stanley Med Coll, 1988

Biography

Dr. Dominic Raj is a Professor of Medicine, Biochemistry & Genetics and Biostatistics and Epidemiology. He is the Director of the Division of Renal Diseases and Hypertension at the George Washington University School of Medicine and Health Sciences.  
 
Dr. Raj is a Fellow of the American College of Physicians and a Fellow of the American Society of Nephrology.  He has received a number of awards and recognition from various national and international institutions including the Distinguished Researcher Award from GW in 2014.  
 
His clinical and research activities pertains to nephrology, hypertension and cardiovascular disease in patients with chronic kidney disease.

During his tenure at the George Washington University, Dr. Raj expanded the research portfolio, added new clinical services and revamped the educational program. He established a number of sub-specialty clinics such as the glomerular diseases clinic, kidney stone clinic, ultrasound clinic. He is pivotal to establishing the kidney transplant program at GW. He has been named Washington Top Doctor multiple times. Dr. Raj has been invited as a visiting professor to number of prestigious institutions. He has organized and chaired symposium for the American Society of Nephrology on multiple occasions. He is highly respected researcher and his research has been continuously funded by the National Institute of Health since 2003.

Clinical Service:

  • Chronic Kidney Disease
  • Adult Polycystic Kidney Disease  
  • Hypertension
  • Cardiorenal syndrome
  • Diabetic Kidney Disease  

Expertise:

  • Hypertension
  • Cardiorenal Syndrome  
  • Novel Dialysis Therapies  

Research

Dr. Raj has conducted cutting-edge patient-oriented as well as laboratory-based research in complex clinical syndromes, including protein kinetics, genetic epidemiology, inflammation, cardiovascular disease, by applying rigorous epidemiological methods and translational research strategies to characterize dominant risk mechanisms and potential treatment strategies.

Inflammation in chronic kidney disease (CKD) is a challenging and complex problem of immense importance to nephrology as well as related fields, including cardiology and nutrition.  In a series of experiments we demonstrated that cytokines cause functional deficiency of amino acids and the amino acids are diverted from muscle protein synthesis to acute phase protein synthesis in the presence of inflammation. We also showed that pro-inflammatory cytokines induce mitochondrial dysfunction and apoptosis in skeletal muscle.
 
In order to understand the consequence of inflammation in chronic kidney disease (CKD), Dr. Raj forged a collaborative relationship with the Chronic Renal Insufficiency Cohort (CRIC) study, this effort was funded by NIDDK. We demonstrated that inflammatory cytokines are elevated in CKD and underpins progression of CKD and CVD.
 
In order to understand the cause for inflammation in CKD, Dr. Raj is conducting research examining the association between intestinal dysbiosis and inflammation in patients with CKD and end-stage renal disease (ESRD). This research is funded by NIDDK through a U0-1 mechanism through Pilot Clinical Trials in CKD consortium and Hemodialysis Novel Therapy Consortium.  
 

Community Service

  • Member of the Clinical Integrative Cardiovascular study section
  • Board of Directors of the National Kidney Foundation

Division

  • Renal Diseases and Hypertension

Publications

View publications by this faculty member from January 1, 2013 - present

Poesen R, PhD, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P,Meijers B, Raj DS. Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with chronic kidney disease. C J Am Soc Nephrol (In press)

Poesen R, PhD, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P,Meijers B, Raj DS. Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with chronic kidney disease. C J Am Soc Nephrol (In press)

Gupta J, Dominic EA, Fink JC, Ojo AO, Barrows IR, Reilly MP, Townsend RR, Joffe MM, Rosas SE, Wolman M, Patel SS, Keane MG, Feldman HI, Kusek JW, Raj DS. Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study. PLos one, 2015 (In press)

Wing MR, Devaney JM, Joffe MM, Raj DS. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study. Nephrol Dial Transplant 29:864-72, 2014.

Rambod, M, Heine GH, Seiler S, Dominic EA, Rogacev KS, Dwivedi RS, Ramezani A, Wing MR, Fliser D, Raj DS: Association of vascular endothelial factors with cardiovascular outcome and mortality in chronic kidney disease patients: A 4-year cohort study. Atherosclerosis. 236):360-365, 2014

Ramezani A, Raj DS: Gut microbiome, kidney disease and targeted interventions J Am Soc Nephrol 25:657-70. 2014

Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT, Jr., Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ: APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease. N Engl J Med 369(23):2183-96, 2013

Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, Periera BG, Feldman HI, Kusek JW, Joffe MM, Raj DS: Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile. Clin J Am Soc Nephrol 7:1938-1946, 2012

Raj DSC, Carrero JJ, Shah VO, Barany P, Heimburger O, Ferguson J , Moseley PL, Stenvinkel P: Soluble CD14 level and protein energy wasting, inflammation complex in ESRD. Am J Kidney Dis; 54:1072-1080, 2009

Shah V, Scariano J, Waters D, Qualls C, Morgan M, Pickett G, Gasparovic C, Dokladny K, Moseley P, Raj DSC: Mitochondrial DNA deletions and sarcopenia. Genetics in Medicine 11, 147-152, 2009

Raj DSC, Moseley P, Dominic EA, Onime A, Tzamaloukas AT, Boyd A, Shah VO, Glew R, Wolfe R, Ferrando A: Interleukin-6 modulates Hepatic and muscle protein synthesis during hemodialysis. Kidney Int 73 1054-1061, 2008

Raj DS, Lim G, Levi M, Qualls C, Jain SK, Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy: Am J Kidney Dis 43, 154-160, 2004

Raj DS, B Vincent, K Simpson, Sato E, Jones KL, Welbourne TC, Levi M, Shah V, Blandon P, Zager P, Robbins R: Hemodynamic changes during hemodialysis: Role of nitric oxide and endothelin. Kidney Int, 61 (2), 697-704, 2002

Raj DS, Self M, Work J: Hybrid Dialysis; Recirculation peritoneal dialysis revisited. Am J Kidney Dis, 36 (1),58-67, 2000

Raj DS, Ouwendyk M, Francoeur R, Uldall R, Pierratos A: Beta2 Microglobulin kinetics in nocturnal hemodialysis. Nephrol Dial Transplant. 15, 58-64, 2000

Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None