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Ahdeah Pajoohesh-Ganji Ahdeah Pajoohesh-Ganji
Assistant Professor of Anatomy and Cell Biology

Office Phone: 202-994-6993
Email: Email
Department: Anatomy and Cell Biology

Education

  • B.S., George Washington University, 1997
  • PhD, George Washington University, 2005

Biography

Background

BS (1997), Major in Biology, Department of Biological Sciences. The George Washington University.
PhD (2005) Major in Biology, Department of Biological Sciences, under the mentorship of Dr Mary Ann Stepp and Dr. Ronald Donaldson. The George Washington University.
Post-doctoral training (2005-2007), Neuroscience Department, under the mentorship of Dr William Rebeck.  Georgetown University.
Post-doctoral training (2007-2010), Neuroscience Department, under the mentorship of Dr Alan Faden.  Georgetown University.

Research Scientist (2010-2013), Department of Anatomy and Regenerative Biology. The George Washington University.

Assistant Research Professor (2013-Present), Department of Anatomy and Regenerative Biology. The George Washington University.

Research

Dr. Pajoohesh-Ganji’s research is focused on the pathways and repair mechanisms that play a role in Multiple Sclerosis (MS). She has used different models such as spinal cord and the optic nerve to investigate questions regarding inflammation, axonal re-growth, and oligodendrocytes biology in mice and rats. Her current research focuses on demyelination and remyelination in the mouse optic nerve.

In addition to her research interests, she also enjoys teaching and training graduate and undergraduate students who rotate in the lab.

Publications

View publications by this faculty member.

Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR. (2012) Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res. 1475:96-105.

Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. (2012) Corneal goblet cells and their niche: implications for corneal stem cell deficiency. Stem Cells 30: 2032-43.

Wu J, Stoica BA, Dinizo M, Pajoohesh-Ganji A, Piao C, Faden AI. (2012) Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury. Cell Cycle. 11: 1782-95.

Whittaker MT, Zai LJ, Lee HJ, Pajoohesh-Ganji A, Wu J, Sharp A, Wyse R, Wrathall JR. (2012) GGF2 (Nrg1-?3) treatment enhances NG2+ cell response and improves functional recovery after spinal cord injury. Glia. 60: 281-94.

Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Stepp MA. (2011) Removal of the basement membrane enhances corneal wound healing. Exp Eye Res. 93(6): 927-936.

Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA. (2011) MMP9 cleavage of the ?4 integrin ectodomain leads to recurrent epithelial erosions in mice. J Cell Sci. 124: 2666-75.

Pajoohesh-Ganji A, Byrnes KR, Fatemi G, Faden AI. (2010) A combined scoring method to assess behavioral recovery after mouse spinal cord injury. Neurosci Res. 67: 117-25.

Loane DJ, Stoica BA, Pajoohesh-Ganji A, Byrnes KR, Faden AI. (2009) Activation of metabotropic glutamate receptor 5 (mGLUR5) modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem. 284: 15629-39.

Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI. (2009) Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 66: 63-74

Hoe HS, Fu Z, Makarova A, Lee JY, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD , Vicini S, Pak DTS, Rebeck GW. (2009)The effects of amyloid precursor protein on post-synaptic composition and activity. J Biol Chem 284:8495-506.

Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW. (2008) Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J Neurotrauma. 25:1087-98.

Burns MP, Vardanian L, Pajoohesh-Ganji A, Wang L, Cooper M, Harris DC, Duff K, Rebeck GW. (2006) The effects of ABCA1 on cholesterol efflux and A-beta levels in vitro and in vivo. J of Neurochem. 98: 792-800.

Pajoohesh-Ganji A, Pal-Ghosh S, Simmens SJ, Stepp MA. (2006)Integrins in slow cycling corneal epithelial cells at the limbus in the mouse. Stem Cells. 24: 1075-1086.

Pajoohesh-Ganji A, Stepp MA. (2005) In search of markers for the stem cells of the corneal epithelium. Biol Cell. 97: 265-276.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None