Madeline Rice, PhD, MS

Madeline Murguia Rice is an Associate Professor in the Department of Epidemiology and Biostatistics at The George Washington University School of Public Health and Health Services.

• Phone: (202) 994-2696 or (301) 816-8039
• Fax: (202) 994-0082 or (301) 881-5928
• Email: mmrice@gwu.edu or mrice@biostat.bsc.gwu.edu

Professor Rice was a doctoral student at the University of Washington when she collaborated on her first cohort study, designed to measure the prevalence, incidence and risk factors for dementia among older Japanese Americans; she has been interested in the methodological challenges of studying older populations ever since. Dr. Rice's research interests now include the two extremes of the life span. She is currently the Principal Investigator and Director of the Clinical and Statistical Coordinating Center of Prevention of Events with Angiotensin Converting Enzyme Inhibition, an NIH–sponsored clinical trial in patients with existing heart disease. She is also a Co–Investigator of the Biostatistics Coordinating Center for the Maternal Fetal Medicine Units Network (MFMU), an NIH–sponsored network that is designed to focus on clinical questions in maternal–fetal medicine and obstetrics. Dr. Rice joined the SPHHS in 2001, and was appointed to The Biostatistics Center faculty in 2002.

A dedicated teacher, Dr. Rice emphasizes public speaking in her classroom in order to help students develop the skills to make presentations, and she encourages students to submit their manuscripts to peer-reviewed journals where appropriate. "An important goal of my teaching is to be a learner as well as a teacher," she says. "I take student feedback to heart and use that input to strengthen my courses and improve the mentoring process. I appreciate learning about new approaches from my students."

Education

Bachelor of Science (Kinesiology/Exercise Physiology), University of California, Los Angeles, 1985
Master of Science, (Kinesiology/Exercise Physiology), University of California, Los Angeles, 1988
Doctor of Philosophy (Epidemiology), University of Washington, 1999

Teaching

PubH 247-Design of Health Studies, Department of Epidemiology and Biostatistics
PubH 248-Epidemiologic Methods in Older Populations, Department of Epidemiology and Biostatistics

Research

Dr. Rice's areas of research interest include chronic disease epidemiology; epidemiology of aging; functional status; hormonal and metabolic aspects of health; biomarkers; maternal and fetal medicine; randomized clinical trials; and multi-center coordination.

Community Service

Professor Rice reviews manuscripts for Journal of the American Medical Association, Ethnicity and Disease, Public Health Nutrition and other scientific journals. She also reviews grants for the National Institute on Aging and the National Heart, Lung and Blood Institute.

Departments

• Epidemiology and Biostatistics

Institutes & Centers

• Biostatistics Center

Research Activities

• Epidemiology of Dementia in Older Japanese Americans (The Kame Project)
• Knoll PEACE supplement (supplement to PEACE NIH contract)
• Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) - Clinical Trial

• Maternal Fetal Medicine Units Network (MFMU)

Publications

• Renal function and effectiveness of angiotensin-converting enzyme inhibitor therapy in patients with chronic stable coronary disease in the Prevention of Events with ACE Inhibition (PEACE) trial.
  Solomon SD, Rice MM, Jablonski KA, Jose P, Domanski M, Sabatine M, Gersh BJ, Rouleau J, Pfeffer MA, Braunwald E, for the Prevention of Events with ACE Inhibition (PEACE) Investigators. Renal function and effectiveness of angiotensin-converting enzyme inhibitor therapy in patients with chronic stable coronary disease in the Prevention of Events with ACE Inhibition (PEACE) trial. Circulation. 2006;114(1):26-31. Epub 2006 Jun 26.
• Obesity and cardiovascular events in patients with established coronary disease.
  Domanski MJ, Jablonski KA, Rice MM, Fowler SE, Braunwald E, for the PEACE Investigators. Obesity and cardiovascular events in patients with established coronary disease. European Heart Journal. 2006;27(12):1416-22. Epub 2006 May 17.
• Is conception delay a risk factor for reduced gestation or birthweight?
  Cooney MA, Buck Louis GM, Sun W, Rice MM, Klebanoff MA. Is conception delay a risk factor for reduced gestation or birthweight? Paediatric and Perinatal Epidemiology. 2006;20(3):201-9.
• Alcohol and cognitive performance: A longitudinal study of older Japanese Americans: The Kame Project.
  Bond GE, Burr RL, McCurry SM, Rice MM, Borenstein AR, Larson EB. Alcohol and cognitive performance: A longitudinal study of older Japanese Americans: The Kame Project. International Psychogeriatrics. 2005;17(4):653-68. Epub 2005 Sep 27.
• Angiotensin-converting-enzyme inhibition in stable coronary artery disease.
  Braunwald E, Domanski MJ, Fowler SE, Geller NL, Gersh BJ, Hsia J, Pfeffer MA, Rice MM, Rosenberg YD, Rouleau JL; PEACE Trial Investigators. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004;351(20):2058-68. Epub 2004 Nov 07.
• Alcohol, Gender, and Cognitive Performance: A longitudinal study comparing older Japanese and non-Hispanic white Americans.
  Bond GE, Burr R, McCurry SM, Rice MM, Borenstein AR, Kukull WA, Teri L, Bowen JD, McCormick WC, Larson EB. Alcohol, Gender, and Cognitive Performance: A longitudinal study comparing older Japanese and non-Hispanic white Americans. J Aging Health 2004:16(5);615-40.
• Alcohol, aging, and cognitive performance: A cross-cultural comparison.
  Bond GE, Burr R, Rice MM, McCurry SM, Graves AB, Teri L, Bowen JD, McCormick WC, Larson EB. Alcohol, aging, and cognitive performance: A cross-cultural comparison. J Aging Health 2003:15(2);371-90.
• Older adults and functional decline: A cross-cultural comparison.
  McCurry SM, Gibbons LE, Bond GE, Rice MM, Graves AB, Kukull W, Teri L, Higdon R, Bowen JD, McCormick WC, Larson EB. Older adults and functional decline: A cross-cultural comparison. Int Psychogeriatr 2002;14(2): 161-79.
• Dietary soy isoflavone intake in older Japanese American women.
  Rice MM, LaCroix AZ, Lampe JW, van Belle G, Kestin M, Sumitani M, Graves AB, Larson EB. Dietary soy isoflavone intake in older Japanese American women. Public Health Nutr 2001;4(5):943-52.
• Ethnicity and cognitive performance among older African Americans, Japanese Americans, and Caucasians: the role of education.
  Shadlen M-F, Larson EB, Gibbons LE, Rice MM, McCormick WC, Bowen J, McCurry SM, Graves AB. Ethnicity and cognitive performance among older African Americans, Japanese Americans, and Caucasians: the role of education. J Am Geriatr Soc 2001;49(10):1371-78.
• Diagnosing osteoporosis in Japanese American women.
  Rice MM, Larson EB, LaCroix AZ, Drinkwater BL. Diagnosing osteoporosis in Japanese American women. Am J Med 2001;110(3):241-42. (Research letter)
• Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame project.
  Rice MM, Graves AB, McCurry SM, Gibbons LE, Bowen JD, McCormick WC, Larson EB. Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame project. Arch Intern Med 2000;160(11):1641-9.
• The dangers of categorizing BMI: reply
  Rice MM, Jablonski KA, Fowler SE, Domanski MJ, Braunwald E. The dangers of categorizing BMI: reply. European Heart Journal. 2006;27(23):2904-2904. Epub 2006 Oct 17. (Letter to the editor)
• Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease.
  Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, Domanski MJ, Hsia J, Gersh BJ, Rifai N, Ridker PM, Pfeffer MA, Braunwald E, for the PEACE Investigators. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007;115(12):1528-36. Epub 2007 Mar 19.
• Long-term trandolapril treatment is associated with reduced aortic stiffness. The prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy.
  Mitchell GF, Dunlap ME, Warnica W, Ducharme A, Arnold JMO, Tardif J-C, Solomon SD, Domanski MJ, Jablonski KA, Rice MM, Pfeffer MA, for the PEACE Investigators. Long-term trandolapril treatment is associated with reduced aortic stiffness. The prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy. Hypertension. 2007;49(6):1271-7. Epub 2007 Apr 23.
• Prognostic value of B-type natriuretic peptides in patients with stable coronary artery disease: The PEACE trial.
  Omland T, Sabatine MS, Jablonski KA, Rice MM, Hsia J, Wergeland R, Landaas S, Rouleau JL, Domanski MJ, Hall C, Pfeffer MA, Braunwald E, for the PEACE Investigators. Prognostic value of B-type natriuretic peptides in patients with stable coronary artery disease: The PEACE trial. Journal of the American College of Cardiology. 2007;50(3):205-214. Epub 2007 Jun 28.
• Prognostic utility of lipoprotein-associated phospholipase A2 for cardiovascular outcomes in patients with stable coronary artery disease.
  Sabatine MS, Morrow DA, O'Donoghue M, Jablonski KA, Rice MM, Solomon S, Rosenberg Y, Domanski MJ, Hsia J; for the PEACE Investigators. Prognostic utility of lipoprotein-associated phospholipase A2 for cardiovascular outcomes in patients with stable coronary artery disease. Atherosclerosis, Thrombosis and Vascular Biology. 2007;27(11):2463-9. Epub 2007 Aug 31.
• Sudden cardiac death in patients with stable coronary artery disease and preserved left ventricular systolic function.
  Hsia J, Jablonski KA, Rice MM, Sabatine MS, Zabalgoitia M, Maggioni A, Cuddy TE, Domanski MJ, Geller NL, Flaker G, Solomon S, Omland T, Rouleau JL, on behalf of the PEACE investigators. Sudden cardiac death in patients with stable coronary artery disease and preserved left ventricular systolic function. The American Journal of Cardiology. in press.
• The influence of albuminuria on cardiovascular risk in patients with stable coronary artery disease.
  Solomon SD, Lin J, Solomon CG, Jablonski KA, Rice MM, Steffes M, Domanski M, Gersh B, Arnold JMO, Rouleau J, Braunwald E, Pfeffer MA, for the Prevention of Events with an ACE Inhibitor (PEACE) Investigators. The influence of albuminuria on cardiovascular risk in patients with stable coronary artery disease. Circulation. in press.