Paul Levine, MD

Paul H. Levine is a Research Professor in the Department of Epidemiology and Biostatistics and Clinical Professor of Medicine at the GW Medical Center.

• Phone: (202) 994-4582
• Fax: (202) 994-0082
• Email: sphphl@gwumc.edu

Professor Levine had long expected to pursue a career in internal medicine, but he first signed on for a six-year tour with the Public Health Services at the National Cancer Institute and that somehow morphed into a 30-year stint as a Commissioned Officer. When he retired in 1995, Dr. Levine was senior clinical investigator of the NCI's Viral Epidemiology Branch and he continues to hold a guest worker appointment in the Institute's Division of Cancer Epidemiology and Genetics.

Dr. Levine's long-standing ties to some of the nation's top researchers provide a steady flow of guest lecturers into his classroom, and generate numerous research opportunities for his students. Since his 1995 move to George Washington University Professor Levine has become increasingly involved in mentoring MPH, PhD and medical students, especially those involved with cancer-related research. He is co-director of Cancer Prevention and Control of the GW Cancer Institute.

Education

Doctor of Medicine, University of Rochester Medical School, 1963

Teaching

Cancer Epidemiology, Department of Epidemiology and Biostatistics
Current Controversies in Cancer, Department of Epidemiology and Biostatistics
Infectious Agents Associated with Cancer, Department of Epidemiology and Biostatistics

Research

Dr. Levine has long pursued research that emphasizes viral oncology, aggressive breast cancer and chronic fatigue syndrome and has more than 275 publications to his credit. His current focus is cancer epidemiology, including ongoing research on breast cancer aggressiveness, cancer patterns among veterans of the Gulf War and cancer patterns in the District of Columbia. He serves as project officer on more than 10 contracts with the National Institutes of Health and chairs the Biospecimen Repository Governing Board of the National Cancer Institute's epidemiology and Biostatistics Program. As an ISCOPES preceptor, Dr. Levine guides a multidisciplinary group of students working on health-related problems of the aging.

Community Service

Most of Professor Levine's community service activities are aimed at confronting the significant cancer problem in the District of Columbia. Towards that goal, he chairs the Advisory Board of the DC Cancer Registry, works with the DC Cancer Coalition to develop a cancer control plan and is involved with the DC Cancer Consortium, which develops new programs that involve all the major hospitals in the District.

Departments

• Epidemiology and Biostatistics

Research Activities

• Cancer Patterns in Gulf War Era Veterans
• Development of an Inflammatory Breast Cancer Registry
• District of Columbia Citywide Patient Navigation Research Study
• Evaluation of Population Based Data at the DC Department of Health and Analysis of Disparities in Cancer Rates within DC
• Pilot Study for Establishment of an Inflammatory Breast Cancer Registry
• Study of Putative Neurological Syndrome in Gulf War Era Veterans

Publications

• The epidemiology of inflammatory breast cancer
  Anderson WA, Hance K, Levine PH. The epidemiology of inflammatory breast cancer. In: Swain S, editor. Inflammatory breast cancer. In press.
• Genetic variants of DNA repair genes and prostate cancer: a population-based study.
  Ritchey JD, Huang WY, Chokkalingam AP, Gao YT, Deng J, Levine P, et al. Genetic variants of DNA repair genes and prostate cancer: a population-based study. Cancer Epidemiol Biomarkers Prev 2005;14:1703-9.
• Trends in inflammatory breast cancer incidence and survival: the surveillance, epidemiology, and end results program at the National Cancer Institute.
  Hance K, Anderson W, Devesa S, Young HA, Levine PH. Trends in inflammatory breast cancer incidence and survival: the surveillance, epidemiology, and end results program at the National Cancer Institute. J Nat Cancer Inst 2005;97: 966-75.
• Breast cancer aggressiveness in women of African descent.
  Levine P, Veneroso C. Breast cancer aggressiveness in women of African descent. In: Christopher KO, Williams CP, Hunter CF, Olufunmilayo O, editors. Breast cancer in women of African descent. Amsterdam, Holland: Kluwer Academic Publishers; 2005. p. 91-188.
• Is testicular cancer related to Gulf War deployment? Evidence from a pilot population-based study of gulf war era veterans and cancer.
  Levine PH, Young HA, Simmens SJ, Rentz, D, Kofie V, Mahan CM, Kang HK. Is testicular cancer related to Gulf War deployment? Evidence from a pilot population-based study of gulf war era veterans and cancer. Mil Med. In press 2005.
• Increasing evidence for a human breast cancer virus with geographic differences.
  Levine PH, Pogo BG, Coronel S, Woodson K, Klouj A, Melana SM, Mourali N, Holland JF. Increasing evidence for a human breast cancer virus with geographic differences. Cancer 2005;101:721-6.
• The inflammatory breast cancer registry: preliminary findings from 50 patients.
  Levine PH, Zolfaghari L. The inflammatory breast cancer registry: preliminary findings from 50 patients. Breast Cancer Res Treat Suppl 2003;82(1):S158.
• Medical intervention and management.
  Levine PH, Schwartz S, Furst G. Medical intervention and management. In: Jason LA, Fennell PA, Taylor RR, editors. Handbook of chronic fatigue syndrome. Hoboken: John Wiley & Sons, Inc.; 2003. p. 441-54.
• Seroincidence of HTLV-I infection and characterization of seroconverts in Jamaican food handlers.
  VanVeldhuisen P, Walters M, Sawada T, Levine PH, Wilks R, Hanchard B, Hisada M. Seroincidence of HTLV-I infection and characterization of seroconverts in Jamaican food handlers. J Acquir Immune Defic Syndr 2003;33:387-92.
• Factor analysis of fatiguing syndrome in Gulf War Era veterans: implications for etiology and pathogenesis.
  Young HA, Simmens SJ, Kang HK, Mahan CM, Levine PH. Factor analysis of fatiguing syndrome in Gulf War Era veterans: implications for etiology and pathogenesis. J Occup Environ Med 2003 Dec;45 (12):1268-73.
• Histologic grade, stage, and survival in breast carcinoma.
  Henson DE, Chu KC, Levine PH. Histologic grade, stage, and survival in breast carcinoma. Cancer 2003;98:908-17.
• Inflammatory breast cancer is associated with an increased microvessel density compared with non-inflammatory breast cancer.
  McCarthy N, Linnoila I, Merino M, Paik S, Parr A, Levine P, Hewitt S, Swain S. Inflammatory breast cancer is associated with an increased microvessel density compared with non-inflammatory breast cancer. Clin Cancer Res 2002;8:3857-62.
• Human leukocyte antigen (HLA) class I and II alleles and extended haplotypes are consistently associated with nasopharyngeal carcinoma (NPC) in Taiwan.
  Hildesheim A, Apple RJ, Chen CJ, Wang SS, Cheng YJ, Klitz W, Mack S, et al. Human leukocyte antigen (HLA) class I and II alleles and extended haplotypes are consistently associated with nasopharyngeal carcinoma (NPC) in Taiwan. J National Cancer Institute 2002;94 (23):1780-9.
• Evidence for a deployment related Gulf War Syndrome by factor analysis.
  Kang HK, Mahan CM, Lee K, Murphy F, Simmens SJ, Young HA, Levine PH. Evidence for a deployment related Gulf War Syndrome by factor analysis. Arch Environ Health 2002 Jan-Feb;57 (1):61-8.
• Neuromyasthenia and chronic fatigue syndrome (CFS) in northern Nevada/California: A ten-year follow-up of an outbreak.
  Strickland PS, Levine PH, Peterson DL, O'Brien K, Fears T. Neuromyasthenia and chronic fatigue syndrome (CFS) in northern Nevada/California: A ten-year follow-up of an outbreak. J Chronic Fatigue Syndrome 2001;9:3-14.
• Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma.
  Hildesheim A, Dosemeci M, Chan CC, Chen CJ, Cheng YJ, Hsu MM, Chen IH, et al. Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2001;10:1145-53.
• Proceedings of the Nevada chronic fatigue syndrome consensus conference.
  Levine PH, Klimas N, Armitage R, Fredericks R, Stewart J, Torch W, Schwartz S, et al. Proceedings of the Nevada chronic fatigue syndrome consensus conference. J Chronic Fatigue Syndrome 2001;9:53-62.
• Haemophilus influenzae type B in childhood leukemia: A case-control study.
  Groves FD, Sinha D, Kayhty H, Goedert JJ, Levine P. Haemophilus influenzae type B in childhood leukemia: A case-control study. Br J Cancer 2001;85(3):337-40.
• Silicone implants and chronic fatigue syndrome.
  Levine PH, Claman H, Clauw D, Robertson AD, Ketch L. Silicone implants and chronic fatigue syndrome. J Chronic Fatigue Syndrome 2000;7:53-73.
• Chronic fatigue syndrome and cancer.
  Levine, PH, Strickland, P, Peterson D. Chronic fatigue syndrome and cancer. J Chronic Fatigue Syndrome 2000;7:29-38.
• Dietary exposure to nitrite and nitrosamines and risk of nasopharyngeal carcinoma in Taiwan.
  Ward MH, Pan WH, Cheng YJ, Li FH, Brinton LA, Chen CJ, Hsu MH, et al. Dietary exposure to nitrite and nitrosamines and risk of nasopharyngeal carcinoma in Taiwan. Int J Cancer 2000;86: 603-9.