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Travis O'Brien

Travis O'Brien

Associate Research Professor of Pharmacology & Physiology

Office Phone: 202- 994-3373
Email:
Department: Pharmacology & Physiology

Education

  • B.S., Bowling Green State University, 1994
  • PhD, University of Cincinnati, 2000

Teaching

Course Director or Co-Director for:
PHAR 3170
HSCI 3116
PHAR 6207
PHAR 6208
PHAR 6202

Research

My laboratory has two major areas of research. First, we have an interest in elucidating the molecular mechanisms of carcinogenesis for environmental chemicals. In addition, we also investigate the genetic and epigenetic factors that impact fertility and predict response to ovarian stimulation therapy.

Programs

  • Pharmaceutical Sciences

Publications

View publications by this faculty member from January 1, 2013 - present

Green, J.S., O’Brien, T.J., Chiappinelli, V.A. and Harralson, A.H., (2010) Pharmacogenomics Instruction in United States and Canada Medical Schools: Implications for Personalized Medicine. Pharmacogenomics 11(9):1331-40.

Chun, G., Bae, D., O’Brien, T.J., Patierno, S.R. and Ceryak, S. (2010) Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass. Carcinogenesis 31(5):785-93.

O’Brien, T.J., Goodsaid, F., Plack. M, Harralson, A., Harrouk, W., Hales, T.G., Mandel, H.G., Perry, D., Kennedy, K. Sarvazyan, N. and Chiappinelli, V.A. (2009) Development of an Undergraduate Pharmacogenomics Curriculum Pharmacogenomics 10(12): 1979-1986.

O'Brien, T.J., Witcher, P., Brooks, B and Patierno, S.R. (2009) Cr(VI) Mutagenesis requires polymerase zeta-dependent translesion synthesis. Mutat. Res. 663 (1-2), 77-83.

Bae D., Camilli T.C., Chun G., Lal M., Wright K., O'Brien T.J., Patierno S.R. and Ceryak, S. (2009) Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: Enhanced survival and mutagenesis. Mutat. Res. 660(1-2):40-46

Brooks, B., O’Brien, T.J., Ceryak, S., DeFabo, E., Wise, S, Wise, J, Wise, J and Patierno, S.R. (2008) Excision Repair is required for genotoxin-induced mutagenesis in mammalian cells Carcinogenesis, 29(5):1064-9

O’Brien, T.J., Jiang, G.H., Chun, G, Mandel, H.G., Westphal, C.S., Kahen, K., Montaser, A., States, J.C., and Patierno, S.R. (2006) Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease. Mutat. Res. 610(1-2):85-92.

Vilcheck, S.K., Ceryak. S., O’Brien, T.J. and Patierno, S.R. (2006) FANCD2 Monoubiquitination and Activation by Hexavalent Chromium [Cr(VI)] Exposure: Activation is not Required for Repair of Cr(VI)-induced DSBs. Mutat. Res. 610(1-2):21-30.

O’Brien, T.J., Mandel, H.G., Sugden, K.D., Komarov, A.M. Patierno, S.R. (2005) Hypoxia impedes the formation of chromium DNA-adducts in a cell-free system. Biochem Pharmacol 70(12), 1814-22

Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.