Anthony-Samuel LaMantiaProfessor of Pharmacology & Physiology
Office Phone: 202-994-8462
Department: Pharmacology & Physiology
- BA, University of Chicago, 1982
- PhD, Yale University, 1988
Dr. LaMantia's laboratory explores genetic and molecular mechanisms of early forebrain development. We study signaling and transcriptional regulation of forebrain stem cell identity and the role of forebrain developmental regulatory genes in behavioral and psychiatric diseases including schizophrenia and autism. Our work is increasingly focused on how these mechanisms influence the development of neural circuits that process information in the cerebral cortex. These circuits are thought to be the target for developmental pathogenesis that leads to a variety of disorders of cortical circuitry including autism and schizophrenia. In addition, we have an ongoing research interest in molecular mechanisms that specify neural stem cells in the embryonic as well as adult nervous system. Our work on this problem focuses on the specification of the neural stem cell in the olfactory epithelium—the sensory receptor surface in the nasal cavity that mediates the sense of smell. This class of neural stem cells is established in the embryo during mid-gestation, and their progeny are retained in the adult olfactory epithelium throughout life to facilitate ongoing replacement of olfactory sensory receptor neurons that connect directly to the forebrain. The mechanisms that maintain this stem cell provide a superb model for considering neuronal regeneration as well as degenerative disorders including Alzheimer’s and Parkinson’s Disease that disrupt the ongoing replacement of olfactory sensory neurons.
View publications by this faculty member from January 1, 2013 - present
Tucker, E.S., Segall, S., Ghopalikrishna, D., Wu, Y., Vernon, M. Polleux, F. and A-S. LaMantia (2008) Molecular Specification and Patterning of Progenitor Cells in the Lateral and Medial Ganglionic Eminence. J. Neurosci 28:9504-9518.
Maynard, T.M., Meechan, D.M., Dudevoir, M.L., Peters, A.Z., Sugimoto, T.J., Wu, Y., Lieberman, J.A., and A-S. LaMantia (2008) A subset of 22q11 schizophrenia vulnerability genes are associated with synaptic mitochondria. Molecular and Cellular Neuroscience 39: 435-451.
Meechan D.W., Tucker E.S., Maynard T.M.,and A.-S. LaMantia (2009) Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc. Natl. Acad. Sci. USA 106 (38):16434-45.
Tucker E.S., Lehtinen, M.K., Maynard, T.M., Zirlinger, M., Dulac, C, Rawson, N.E., Pevny, L.H., and A.-S. LaMantia (2010) Proliferative and transcriptional identity of two distinct classes of neural precursors in the mammalian olfactory epithelium. Development. 37:2471-81. (PMID: 20573694).
Rawson, N.E., Lischka, F., Yee, K.K., Peters, A.Z., Tucker, E.S., Meechan, D.W., Zirlinger, M., Maynard, T.M., Burd, G.B., Dulac, C., Pevny, L.H., and A.-S. LaMantia, (2010) Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. Dev. Dynamics 239:1723-1738.
Meechan, D.W., Maynard, T.M., Tucker, E.S. and LaMantia A-S. (2011) Three Phases of DiGeorge/22q11 Deletion Syndrome Pathogenesis during brain development: patterning, proliferation, and mitochondrial functions of 22q11 genes. Int. J. Dev. Nsci. 29:283-294.
Lehtinen, M.K., Zappaterra, M.D., Chen, X., Yang, Y.J., Hill, A., Lun, M., Maynard, T.M., Gonzalez, D., Kim, S., Ping, Y., D’Ercole, J.D., Wong, E.T., LaMantia, A-S., and Walsh, C.A. (2011) The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron 69:893-605.
Additional publications published before January 1, 2013 may be available within Himmelfarb Library's database.