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publications, contact information Research Interests
Selected Publications Top Zhan Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Hu Wei, Xiao Shu-hua, Li Tiehua, Gong Xin, Feng Zheng, Peter Hotez. Ancylostoma-secreted Protein 1 (ASP-1) Homologues in Human Hookworms. Mol Biochem Parasitol 1999; 98:143-149 Shan Qiang, Zhan Bin, Xiao shu-hua, Feng Zheng, Peter Hotez , and John M. Hawdon. Variation between ASP-1molecules from Ancylostoma caninum in China and the United States. J. Parasitol. 2000; 86(1):181-5 Bin Zhan, Tiehua Li Shuhua Xiao, Zheng Feng and John M Hawdon. Species-specific Identification of Human Hookworms by PCR of the Mitochondrial Cytochrome Oxidase Gene.J. Parasitol. 2001; 87(5):1227 Bin Zhan, Mahnaz Badamchian, Bo Meihua, James Ashcom, Jianjun Feng, John Hawdon, Xiao Shuhua, and Peter J. Hotez. Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms . Am. J. Trop. Med. Hyg. 2002; 66(3):238-244 Bin Zhan, Peter J Hotez , Yan Wang and John M Hawdon . A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of protease . Mol. Biochem. Parasitol . 2002; 120:291-296 Peter J. Hotez, Zhan Bin, Jeffrey Bethony, Qun Jin, John M. Hawdon, Heather A. Young, Samuel Simmens, Richard Hitzelberg , and Bernard C. Zook. Natural history of primary canine hookworm infections after three different oral doses of third-stage infective larvae of Ancylostoma caninum. Comparative Parasitology 2002 ; 69(1):72-80 . Peter J. Hotez, James Ashcom, Zhan Bin, Jeff Bethony, Angela Williamson, John M. Hawdon, Feng Jianjun, Azra Dobardzic, Ivania Rizo, Janelle Bolder, Qun Jin, Wang Yan, Reshad Dobardzic, Sophia Chung-Debose, Melissa Crowell, Bennett Datu, Angela Delaney, Dilyan Dragonovski, Yang Jiang, Liu Yueyuan, Kshinath Ghosh, Alex Loukas, Walter Brandt, Philip K. Russell, and Bernard C. Zook . Effect of vaccinations with recombinant fusion protein on Ancylostoma caninum habitat selection in the canine intestine . J. Parasitol . 2002; 88(4):684-690 Peter J. Hotez, James Ashcom, Zhan Bin, Jeffrey Bethony, Alex Loukas, John Hawdon, Wang Yan, Qun Jin, Karen C. Jones, Azra Dobardzic, Reshad Dobardzic, Janelle Bolden, Idong Essiet, Walter Brandt, Philip K. Russell, Bernard C. Zook, Brian Howard, and Marco Chacon. Effect of vaccination with a recombinant fusion protein encoding an astacin-like metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae. J. Parasitol 2003; 89(4):853-855 Sridhar Basavaraju, Bin Zhan, Malcolm W. Kennedy, Yueyuan Liu, John Hawdon and Peter J. Hotez . Ac-FAR-1, a 20 kDa Fatty Acid- and Retinol-Binding Protein Secreted by Adult Ancylostoma caninum Hookworms: gene transcription pattern, ligand binding properties and structural characterisation. Molecular and Biochemical Parasitology. 2003; 126:63-71 Bin Zhan, Yueyuan Liu, Mahnaz Badamchian, Angela Williamson, Jianjun Feng, Alex Loukas, John M. Hawdon and Peter J. Hotez. Molecular characterization of the Ancylostoma-secreted Protein (ASP) family from the adult stage of Ancylostoma caninum. Int. J. Parasitol . 2003; 33:897-907 Peter J. Hotez, Bin Zhan, Jeffrey M. Bethony, Alex Loukas, Angela Williamson, Gaddam Narsa Goud, John M. Hawdon, Azra Dobardzic, Reshad Dobardzic, Kashinath Ghosh, Maria Elena Bottazzi, Susana Mendez, Bernard Zook, Yan Wang, Sen Liu, Idong Essiet-Gibson, Sophia Chung-Debose, Shuhua Xiao, David Knox, Michael Meagher, Mehmet Inan, Rodrigo Correa-Oliveira, Paul Vilk, Herman R Shepherd, Walter Brandt, Philip K. Russell, Progress in the development of a recombinant vaccine for human hookworm disease: The Human Hookworm Vaccine Initiative. Int. J. Parasitol 2003 ; 33:1245-58 Gaddam Narsa Goud, Bin Zhan, Kashinath Ghosh, Alex Loukas, John Hawdon, Azra Dobardzic, Vehid Deumic, Sen Liu, Reshad Dobardzic, Bernard C. Zook, Qun Jin, Yueyuan Liu, Laura Hoffman, Sophia Chung-Debose, Rachna Patel, Susana Mendez, and Peter J. Hotez. Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum. J Infect Dis . 2004; 189(5):919-29. Bin Zhan , Yan Wang, Yueyuan Liu, Angela Williamson, Alex Loukas, John M. Hawdon, Xue Hae-chou, Xiao Shu-hua, and Peter J. Hotez. Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. Int. J Parasitol. 2004; 34:1037-45 Bin Zhan, Sen Liu, Samirah Perally, Jian Xue, Ricardo Fujiwara, Peter Brophy, Shuhua Xiao, Yueyuan Liu, Jianjun Feng, Angela Williamson, Yan Wang, Lilian L. Bueno, Susana Mendez, Gaddam Goud, Jeffrey M. Bethony, John M. Hawdon, Alex Loukas, Karen Jones and Peter J. Hotez.Biochemical characterization and vaccine potential of a heme binding glutathione transferase (GST) from the adult hookworm Ancylostoma caninum. Infection and Immunity 2005; 73(10)- Susana Mendez, Bin Zhan, Gaddam Goud, Kashinath Ghosh, Azra Dobardzic, Wenhui Wu, Sen Liu, Vehid Deumic, Reshad Dobardzic, Yueyuan Liu, Jeff Bethony and Peter J. Hotez Effect of combining the larval antigens Ancylostoma Secreted Protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum . Vaccine. 2005; 23:3123-30 Gaddam Narsa Goud, Maria Elena Bottazzi, Bin Zhan, Susana Mendez, Jin Wen, Vehid Deumic, Sen Liu, Jordan Pleiskatt, Maneesha Solanki, Olutoyin Asojo, Allan Saul, Jeffrey M. Bethony, Alex Loukas, Michael Roy, Peter J. Hotez. Cloning, Expression in Pichia pastoris, Purification, and Process Development of the Na-ASP-2 Human Hookworm Vaccine. Vaccine (in press) Contact Information Top Bin Zhan, MD |
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