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 publications, contact information Research Interests Two research programs have directed the attention and efforts of my laboratory over the past 20 years: ( i ) immunity to parasitic protozoa focused on Trypanosoma musculi infections in various strains of normal and mutant mice; and ( ii ) aging of the immune system and functional immune competence. In recent years, the two lines of interest have conjoined and T. musculi has been employed as a prototypic pathogen to identify the elements of immune responses that are inordinately susceptible to senescence. The innate component of the immune system and the effect of aging on the innate responses to T. musculi are the central subjects of current research. In addition to laboratory research, global problems of public health occupy a considerable portion of my time and energy. Our group is involved in programs concerned with intestinal helminth infections among children in Indonesia, Sri Lanka, Cambodia, anemia tuberculosis/malaria in Indonesia and Cambodia, and the impact of HIV/AIDS, poor sanitation and nutrition among children in Mozambique. Selected Publications Top JW Albright, JH Bream, EW Bere, HA Young, R Winkler-Pickett, JR Ortaldo. 2004. Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin - 2. J. Exp.Gerontol. 39, 73-82. JF Albright and JW Albright. 2003. Aging, Immunity and Infection. Humana Press Inc. Totowa, NJ. JW Albright and JF Albright. 2000. Soluble receptors and other substances that regulate proinflammatory cytokines in young and aging humans. J. Gerontol. 25A, B20-25. JW Albright, RC Mease, C Lambert and JF Albright. 1999. Tropanosome musculi tracking parasites and circulating lymphoid cells in host mice. Exp. Parasitol. 91, 185-195. JW Albright and JF Albright. 1998. Impaired natural killer cell function as a consequence of aging. J. Exp. Gerontol. 33, 13-25. JW Albright, D Jiang and JF Albright. 1997. Innate control of early course of infection in mice inoculated with Trypanosome musculi. Cell Immunol. 176, 146-152. Contact Information Top The George Washington University Medical Center
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