March 14-16, 2012
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3:00 – 7:00 PM |
Registration |
The George Washington University |
7:30 PM |
Welcome |
Allan L. Goldstein and Enrico Garaci |
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Co-Chairs of Symposium |
7:40 PM |
Keynote Speakers |
Luigina Romani (U. of Perugia, Perugia, Italy): Thymosin α1: environment-dependent mechanisms of a drug's pleiotropy Deepak Srivastava (U. of California, San Francisco, CA): Thymosin β4 in cardiac regeneration |
8:30 PM |
Reception |
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7:00 – 8:00 AM |
Registration and Breakfast |
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8:00 – 10:00 AM |
Plenary Session I |
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Thymosins: Chemistry, Genetics, Receptors, Signaling, and Multi-Functionality |
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Co-Chairs: |
Bruce Zetter & Cynthia Tuthill |
| Speakers: | John Edwards (University of Glasgow, Glasgow, Scotland, UK): Beta Thymosins: the family history | |
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Milica Radisic (U. of Toronto, Toronto, Canada): Controlled delivery of Thymosin β4 for tissue engineering and cardiac regenerative medicine |
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Francesca Fallarino (U. of Perugia, Perugia, Italy): The unexpected interface between Thymosin α1 toll-like receptors and IDO |
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Gavino Faa (U. of Cagliari, Italy): Expression pattern of Tβ4 in the adult human liver |
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Paola Sinibaldi/Francesca Pica (U. of Rome, Rome, Italy): Thymosin α1: Transcription & Cancer |
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Yeu Su (National Yang-Ming University, Taipei, Taiwan): Thymosin β4: from a G-actin binding protein to a malignancy promoter for human colon cancer |
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Hiroshi Ueda (Nagasaki University, Nagasaki, Japan): Prothymosin alpha: its mechanisms for non-vesucular release and receptor in central nervous system |
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[Additional short talks selected from abstracts] |
10:00 AM |
Coffee Break – 30 minutes |
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10:30 PM – 12:30 PM |
Plenary Session II |
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Thymosins: Molecular Markers, Wound Healing, Fibrosis, Inflammation, and Hypoxia |
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Co-Chairs: |
Ewald Hannappel & Paul Naylor |
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Speakers: |
Gavino Faa (U. of Cagliari, Italy): Expression pattern of Tβ4 in the adult human liver |
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Karina Reyes-Gordillo (The George Washington University School of Medicine, Washington, DC): Thymosin β4 & liver fibrosis |
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Oscar A. Carretero (Henry Ford Hospital, Detroit, MI): Effect of Ac-SDKP in experimental autoimmune myocarditis and in hypertension |
| Enrico Conte (University of Catania, Catania, Italy): Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung | ||
Sprague W. Hazard (Penn State College of Medicine, Hershey, PA): The effects of Thymosin β4 on myofibroblasts, wound breaking strength and cytoskeletal organization |
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Hee-Jae Cha (Kosin University, Busan, S. Korea): Thymosin β4 stabilizes hypoxia-inducible factor-1α by oxygen independent manner |
12:30 – 2:00 PM |
Lunch |
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2:00 – 4:00 PM |
Plenary Session III |
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Thymosin β4: Cardiovascular Protection, Neuroplasticity and Regeneration, and Stem Cell Differentiation |
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Co-Chairs: |
Deepak Srivastava & Paul Riley |
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Speakers: |
Sudhiranjan Gupta (Texas A&M Health Science Center, Temple, TX): Thymosin beta 4 and cardiac protection: implication of inflammation and fibrosis |
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Nicola Smart (University College London, London, England): Thymosin β4 facilitates myocardial regeneration via activated epicardial progenitor cells |
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Christian Kupatt (Ludwig-Maximilians-University of Munich, Munich, Germany): Thymosin β4-induced biological bypasses: Mechanisms of arteriogenesis in ischemic muscle tissue |
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Dan Morris (The Henry Ford Health System, Detroit, MI): Mechanisms of Tβ4-mediated oligodendrogenesis after stroke |
R. Hinkel (Klinikum der Universitat Munchen, Munchen, Germany): Thymosin β4: molecular mechanism in angio- /arteriogenesis |
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Christoffer Stark (Turku University Central Hospital, Finland): Cardioprotective effects of Thymosin β4 after myocardial infarction |
4:00 – 5:30 PM |
Poster Presentations and Coffee |
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7:00 – 9:30 PM |
Awards Banquet |
Italian Embassy |
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2012 Abraham White Scientific, Humanitarian, and Public Service Awardees
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To be announced |
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To be announced |
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7:00 – 8:00 AM |
Breakfast |
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8:00 – 10:00 AM |
Plenary Session IV |
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Thymosin α1: Immunomodulation, Immunopharmacology, Infectious Diseases, and Cancers |
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Co-Chairs: |
Enrico Garaci & Roberto Camerini |
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Speakers: |
Hemmo Drexhage (Erasmus Medical College, Rotterdam, The Netherlands): The gene expression abnormalities of motility disturbed monocytes in recurrent and chronic purulent rhino-sinusitis. Correction by thymosins. |
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Michele Maio (Centro di Riferimento Oncologico of Aviano, Italy): Thymosin α1 in melanoma: from the clinical trial setting to the daily practice |
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Annalucia Serafino (National Research Council of Italy, Rome, Italy): Thymoin α1 as a stimulatory agent for the early macrophage-mediated immune defence against fungal pathogens |
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Andrea Velardi (U. of Perugia, Perugia, Italy): Bone marrow transplanted patients treated with Tα1 to prevent infections |
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Roberto Camerini (Sigma-Tau, Rome, Italy): Thymosin α1 as adjuvant for H1N1 vaccination in end stage renal disease patients |
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Cynthia Tuthill (SciClone Pharmaceuticals, San Francisco, CA): Thymosin α1 continues to show promise as an enhancer for vaccine response |
10:00 AM |
Coffee Break |
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10:30 AM – 12:30 PM |
Plenary Session V |
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Clinical and Preclinical Applications of Thymosin β4: Wound Healing, Eye Injuries, Cardiovascular Diseases and Neurological Injuries |
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Co-Chairs: |
David Crockford & Gabriel Stone |
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Speakers: |
Mark Hardy (Columbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York City, NY): The role of Thymosin β4 in healing of acute and chronic wounds |
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Gabe Sosne (Wayne State University School of Medicine, Kresge Eye Institute, Detroit, MI)Thymosin beta 4: A potential novel dry eye therapy |
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Xe Xiong/Michael Chopp (The Henry Ford Health System, Detroit, MI): Post-traumatic treatment with Thymosin β4 improves functional recovery after traumatic brain injury in rats: neuroprotective and neurorestorative effects |
12:30 – 2:00 PM |
Lunch |
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2:00 – 3:30 PM |
Plenary Session VI |
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| Late Breaking Paper Session | ||
| Co-Chairs: | Hynda Kleinman & Allan Goldstein | |
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Speakers: |
Domenico Schillaci (Università degli Studi di Palermo, Palermo, Italy): Fragments of beta-thymosin from the sea-urchin Paracentrotus lividus as novel antimicrobial peptides against Staphylococcal biofilms |
3:30 PM |
Adjournment |
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