Research Interests

Role of nitric oxide and oxidative stress in inflammation and shock; Mechanism(s) of iron toxicity in vivo and in vitro; and Biomedical applications of EPR(ESR) spectroscopy and spin trapping

Research Program

My research is focused on the role of nitric oxide (NO), reactive oxygen species (ROS) and iron in inflammation, shock (septic shock, hemorrhagic shock) and several nutritional models (iron overload, magnesium deficiency). In particular, I am interested in interactions between NO, ROS and iron pathways in cells and tissues. I am also working on the mechanisms of iron and azidothymidine (AZT) toxicity in vivo and in vitro. My research involves development of the new techniques and approaches for detection of free radicals and redox-active metals.

Selected Publications

• Kramer, J.H., Spurney, C., Iantorno, M., Tziros, C., Mak, I.T., Tejero-Taldo, M.I., Chmielinska, J.J., Komarov, A.M., Weglicki, W.B. Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia. Am. J. Med. Sci.,338:22-27, 2009.
• Komarov, A.M. Commentary on “Reduction of hexavalent chromium by human cytochrome b5: Generation of hydroxyl radical and superoxide”. Free Radical Biol. & Med., 42:735-737, 2007.
• Komarov, A.M., Hall, J.M., Chmielinska, J.J., Weglicki, W.B. Iron uptake and release by macrophages is sensitive to propranolol. Mol. Cell. Biochem., 288:213-217, 2006.
• Komarov, A.M., Hall, J.M., Weglicki, W.B. Azidothymidine (AZT) promotes free radical generation by activated macrophages and hydrogen peroxide-iron mediated oxidation in a cell-free system. Biochim. Biophys. Acta 1688:257-264, 2004.
• Komarov, A.M. Chemistry and biology of nitric oxide. In: Biological Magnetic Resonance, Kluwer, 2003, 18, 325-379.
• Komarov, A.M., Reif, A., Schmidt, H.H.H.W. In vitro detection of nitric oxide and nitroxyl by EPR. Meth. Enzymol. (Nitric Oxide, part D) 359: 18-27, 2002.