Research Interests

Basic biomedical research of vascular diseases and aging: Currently focuses on the Fas-induced apoptosis signaling pathway and the mechanism of interferon gamma regulated balance of apoptotic factors in human vascular lesion cell, by using functional genomic tools such as genechip, gene cloning and expression, and RNA Interference et al.

Selected Publications:

1. Zhaoqing Yang , Dmitry Gagarin, Ali Ramezani, Robert G. Hawley, and Timothy A. McCaffrey, Resistance to fas-induced apoptosis in cells from human atherosclerotic lesions: Elevated Bcl-XL inhibits apoptosis and caspase activation. Journal of vascular research, 2007, 483-94.[pubMed]

2. Manali Mody, Nachiket Dharker, Mark Bloomston, Pei-Shan Wang, Fu-Sheng Chou, Theodore S Glickman, Timothy McCaffrey, Zhaoqing Yang, Anne Pumfery, Daniel Lee, Matthew D Ringel , and Joseph J Pinzone. Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-a, CH11 and CYC202. Endocrine-Related Cancer. 2007, 14: 1–12. [pubMed]

3. Dmitry Gagarin, Zhaoqing Yang, Jason Butler, Monika Wimmer, Baoheng Du, Patrick Cahan, Timothy A. McCaffrey. Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL. J Mol Cell Cardiol. 2005, 39(3):453-65. [pubMed]

4. Jia-you Chu, Wei Huang, Sao-qing Kuang, Jian-ming Wang, Jiu-jin Xu ,Zheng-tao Chu, Zhao-qing Yang, Ke-qin Ling, Pu LI, Min Wu, Z-c Geng, C-c Tang, Ro-fu Du, Li Jin. Genetic relationship of populations in China. Proc Natl Acad Sci.USA, 1998, 95:11763-11768.[pubMed]