Dr. Mak I.Tong Mak, Associate Research Professor, Free radical pathobiology in cardiovascular cells; Antioxidant drug mechanisms and therapy; Iron and AZT toxicity; Mg-deficiency.

Contact Information

Office: Ross Hall, Rm 443A
Lab: Ross Hall, Rm 443
Tel: (202) 994-2865
Fax: (202) 994-3553 or 202-994-3549
E-mail: itmak@gwu.edu

Research Interests

  • Cardiovascular inflammation and oxidative stress.
  • Antioxidant properties of ß-blockers and Ca-channel antagonists.
  • Endothelial modeling of oxidative injury, apoptosis and drug therapy.
  • The role of lysosomes in iron overloading.
  • Magnesium deficiency and systemic inflammation.
  • Pro-oxidative properties of AZT.
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    Selected Publications:

    1. Mak IT, Weglicki WB: Potent Antioxidant Properties of 4-OH-Propranolol. J. Pharmacol. Exp. Therap.308:85-90, 2004.
    2. Tejero-Taldo, MI, Chmielinska J, Gonzalez G, Mak IT, Weglicki WB: NMDA receptor blockade inhibits cardiac inflammation in the Mg-deficient rat. J. Pharmacol. Exp. Therap.(In press ) 2004.
    3. Mak IT, Nedelec LF, Weglicki WB: Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT. Cardiovascular Toxicology (In Press) 2004.
    4. Mak IT, Kramer JH, Weglicki WB:Suppression of Neutrophil and Endothelial Activation by Substance P-Receptor Blockade in the Mg-Deficient Rat. Magnesium Res.16:91-97, 2003.
    5. Mak IT, Zhang J, Weglicki WB: Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to NO and superoxide. Pharmacol Res.45:27-33, 2002.
    6. Dickens BF, Weglicki WB, Boehme P, Mak IT: Antioxidant and lysosomotropic properties of acridine- propranolol: Protection against oxidative endothelial injury. J Mol Cell Cardiol 34: 129-137, 2002.
    7. Mak IT, Komarov AM, Kramer JH, Weglicki WB: Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity. Cellular and Molecular Biology 46: 1337-1344, 2000.
    8. Mak IT, Zhang J, Weglicki WB: Cytoprotective properties of nisoldipine and amlodipine against oxidative endothelial cell injury. Ann. New York Acad. Sci.899: 399-402, 2000.
    9. Mason RP, Mak IT, Trumbore MW, Mason PE: Antioxidant properties of calcium antagonists related to membrane biophysical interactions. Am. J. Cardiol.84:16L-22L, 1999.
    10. Mak IT, Murphy A, Hopper A, Witiak D, Ziemniak J, Weglicki WB: Potent inhibitory activities of hydrophobic aci-reductones against membrane and human LDL oxidation.Biochem. Pharmacol.55:1921-26, 1998.
    11. Mak IT, Dickens BF, Komarov A, Wagner T. Weglicki WB: Activation of the neutrophil and loss of plasma glutathione during Mg-deficiency—Modulation by nitric oxide synthase inhibition. Mol.Cell.Biochem.176:35-39, 1997.
    12. Mak IT, Komarov A, Wagner T. Stafford R, Dickens BF, Weglicki WB: Enhanced nitric oxide production during Mg-deficiency and its role in mediating red cell glutathione loss. Am. J. Physiol.271:C385-C390, 1996.
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