|
|
|
|
Contact Information |
| Office: |
Ross Hall, Rm 443A |
| Lab: |
Ross Hall, Rm 443 |
| Tel: |
(202) 994-2865
|
| Fax: |
(202) 994-3553 or 202-994-3549 |
| E-mail: |
itmak@gwu.edu |
|
Research Interests
Cardiovascular inflammation and oxidative stress.
Antioxidant properties of ß-blockers and Ca-channel antagonists.
Endothelial modeling of oxidative injury, apoptosis and drug therapy.
The role of lysosomes in iron overloading.
Magnesium deficiency and systemic inflammation.
Pro-oxidative properties of AZT.
return to top
|
|
Selected Publications:
- Mak IT, Kramer JH, Chmielinska et al.. Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat. Inflammation Res. 57: 300-305, 2008.
- Tejero-Taldo MI, Kramer JH, Mak IT, Komarove AM, Weglicki WB. The nerve-heart connection in the pro-oxidant response to Mg-deficiency. Heart Fail Rev. 11: 35-44, 2007
- Mak IT , Chmielinska JJ, Torres A, Weglicki WB. D-propranolol attenuates lysosomal iron accumulation and oxidative injury in endothelial cells. J Pharmacol ExpTher.;317(2):522-8. 2006.
- Mak IT , Weglicki WB: Potent antioxidant properties of 4-OH-propranolol. J. Pharmacol.. Exp. Ther. 308: 85-90; 2004.
- Mak IT , Goldfarb MG, Weglicki WB, Haudenschild CC. Cardiac pathologic effects of AZT in Mg-deficient mice. Cardiovas. Toxicol. 4: 169-178; 2004
- Tejero-Taldo MI, Chmielinska JJ, Gonzalez G, Mak IT, Weglicki WB. N-Methyl-D-aspartate receptor blockade inhibits cardiac inflammation in the Mg-deficient rat. J. Pharmacol.. Exp. Ther. 311: 8-13; 2004.
- Mak IT, Kramer JH, Weglicki WB: Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient rat. Magnesium Res. 16(2):91-97, 2003.
- Mak IT, Zhang J, Weglicki WB: Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to NO and superoxide. Pharmacol Res. 45:27-33, 2002.
- Dickens BF, Weglicki WB, Boehme P, Mak IT: Antioxidant and lysosomotropic properties of acridine-propranolol: Protection against oxidative endothelial injury. J Mol Cell Cardiol 34: 129-137, 2002
- Mak IT, Komarov AM, Kramer JH, Weglicki WB: Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity. Cellular and MolecularBiology 46: 1337-1344, 2000.
- Mason RP, Mak IT, Trumbore MW, Mason PE. Antioxidant properties of calcium antagonists related to membrane biophysical interactions. Am J Cardiol. 1999 Aug 19;84(4A):16L-22L.
- Mak IT, Murphy A, Hopper A, Witiak D, Ziemniak J, Weglicki WB: Potent inhibitory activities of hydrophobic aci-reductiones against membrane and human LDL oxidation. Biochem. Pharmacol. 55:1921-26, 1998.
- Mak IT , Komarov A, Wagner T. Stafford R, Dickens BF, Weglicki WB: Enhanced nitric oxide production during Mg-deficiency & its role in mediating red cell glutathione loss. Am. J. Physiol. 271:C385-C390, 1996
|
|
return to top
|
|
|
|
|
View faculty by location:
|
