|
|
|
|
Contact Information |
| Office: |
Ross Hall, Rm 443A |
| Lab: |
Ross Hall, Rm 443 |
| Tel: |
(202) 994-2865
|
| Fax: |
(202) 994-3553 or 202-994-3549 |
| E-mail: |
itmak@gwu.edu |
|
Research Interests
Cardiovascular inflammation and oxidative stress.
Antioxidant properties of ß-blockers and Ca-channel antagonists.
Endothelial modeling of oxidative injury, apoptosis and drug therapy.
The role of lysosomes in iron overloading.
Magnesium deficiency and systemic inflammation.
Pro-oxidative properties of AZT.
return to top
|
|
Selected Publications:
- Mak IT, Weglicki WB: Potent Antioxidant Properties of 4-OH-Propranolol. J. Pharmacol. Exp. Therap.308:85-90, 2004.
- Tejero-Taldo, MI, Chmielinska J, Gonzalez G, Mak IT, Weglicki WB: NMDA receptor blockade inhibits cardiac inflammation in the Mg-deficient rat. J. Pharmacol. Exp. Therap.(In press ) 2004.
- Mak IT, Nedelec LF, Weglicki WB: Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT. Cardiovascular Toxicology (In Press) 2004.
- Mak IT, Kramer JH, Weglicki WB:Suppression of Neutrophil and Endothelial Activation by Substance P-Receptor Blockade in the Mg-Deficient Rat. Magnesium Res.16:91-97, 2003.
- Mak IT, Zhang J, Weglicki WB: Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to NO and superoxide. Pharmacol Res.45:27-33, 2002.
- Dickens BF, Weglicki WB, Boehme P, Mak IT: Antioxidant and lysosomotropic properties of acridine- propranolol: Protection against oxidative endothelial injury. J Mol Cell Cardiol 34: 129-137, 2002.
- Mak IT, Komarov AM, Kramer JH, Weglicki WB: Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity. Cellular and Molecular Biology 46: 1337-1344, 2000.
- Mak IT, Zhang J, Weglicki WB: Cytoprotective properties of nisoldipine and amlodipine against oxidative endothelial cell injury. Ann. New York Acad. Sci.899: 399-402, 2000.
- Mason RP, Mak IT, Trumbore MW, Mason PE: Antioxidant properties of calcium antagonists related to membrane biophysical interactions. Am. J. Cardiol.84:16L-22L, 1999.
- Mak IT, Murphy A, Hopper A, Witiak D, Ziemniak J, Weglicki WB: Potent inhibitory activities of hydrophobic aci-reductones against membrane and human LDL oxidation.Biochem. Pharmacol.55:1921-26, 1998.
- Mak IT, Dickens BF, Komarov A, Wagner T. Weglicki WB: Activation of the neutrophil and loss of plasma glutathione during Mg-deficiency—Modulation by nitric oxide synthase inhibition. Mol.Cell.Biochem.176:35-39, 1997.
- Mak IT, Komarov A, Wagner T. Stafford R, Dickens BF, Weglicki WB: Enhanced nitric oxide production during Mg-deficiency and its role in mediating red cell glutathione loss. Am. J. Physiol.271:C385-C390, 1996.
|
|
return to top
|
|
|
|
|
View faculty by location:
|
