|
|
|
|
Contact Information |
| Office: |
Ross Hall, Rm 435 A |
| Lab: |
Ross Hall, Rm 435, 445, 415 |
| Tel: |
(202) 994-0502
|
| Fax: |
(202) 994-3553 |
| E-mail: |
phyjhk@gwumc.edu |
|
Research Interests
Mechanism(s) through which dietary Mg-restricted diets mediate a pro-inflammatory/Oxidative condition in rodent models, with emphasis on dietary threshold levels.
The impact of dietary Mg-restricted diets on rat hearts subjected to ischemia / reperfusion (I/R) stress.
Investigate the neuropeptide release mechanism exhibited by postischemic rat hearts as well as normally-perfused rat hearts exposed to varying perfusate Mg concentrations.
The influence of chronic AZT treatment on tissue iron content in normal and Mg-restricted rodents, and changes in cardiac susceptibility to I/R stress.
The involvement of endogenous iron redistribution as a mechanism to explain the beneficial effects of pre-conditioning on myocardial tissue subjected to severe postischemic stress.
Determine the exogenous iron threshold level which predisposes hearts to I/R stress.
Assess the acute and chronic antioxidant effects of d-propranolol and its analogs on I/R hearts from iron-loaded rats.
return to top
|
|
Selected Publications:
- Kramer, J.H. and Weglicki, W.B. A hydroxylated analog of the ß-adrenoceptor antagonist, carvedilol, affords exceptional antioxidant protection to postischemic rat hearts. Free Rad. Biol. Med. 21(6):813-826, 1996.
- Kramer, J.H. and Weglicki, W.B. Magnesium-deficiency enhanced postischemic myocardial injury is reduced by substance P receptor blockade. J. Mol. Cell. Cardiol. 29:97-110, 1997.
- Komarov, A.M., Kramer, J.H., Mak, I-T., and Weglicki, W.B. EPR detection of endogenous nitric oxide in postischemic heart using lipid and aqueous-soluble dithiocarbamate-iron complexes. Mol. Cell. Biochem. 175:91-97, 1997.
- Kramer, J.H., Lightfoot, F., and Weglicki,, W.B. Cardiac tissue iron: effects on postischemic function and free radical production, and its possible role during preconditioning. Cellular and Molecular Biology 46(8):1313-1327, 2000.
- Mak, I-T., Komarov, A.M., Kramer, J.H., and Weglicki, W.B. Cytoprotective properties of Mg-gluconate. Cellular and Molecular Biology 46(8):1337-1344, 2000.
- Weglicki, W.B., Kramer, J.H., Mak, I-T., Dickens, B.F., and Komarov, A.M. Pro-oxidant and pro-inflammatory neuropeptides in magnesium deficiency. In: Advances in Magnesium Research: Nutrition and Health, Proceedings of the 9th International Magnesium Symposium, eds. Rayssiguier, Y., Mazur, A., Durlach, J., John Libbey & Co., Ltd., Paris, pp. 285-289, 2001.
- Schaffer, S.W., Pastukh, V., Solodushko, V., Kramer, J. and Azuma, J. Effect of ischemia, calcium depletion and repletion, acidosis and hypoxia on cellular taurine content. Amino Acids 23:395-400, 2002.
- Murthi, S.B., Wise, R.M., Weglicki, W.B., Komarov, A.M., and Kramer, J.H. Mg-Gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfate. Mole. Cell. Biochem. 245:141-148, 2003.
- Kramer, J.H. , Mak, I. T., Phillips, T.M., and Weglicki, W.B. Dietary Mg-intake influence circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress Exp. Biol. Med. 228:665-673, 2003.
- Mak I-T., Kramer J.H., and Weglicki W.B. Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient rat. Magnesium Res. 16(2):91-97, 2003.
|
|
return to top
|
|
|
|
|
View faculty by location:
|
