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Andrei M. Komarov
Assistant Research Professor
Cardiovascular Disease, Nitric Oxide, Oxidative Stress |
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Contact Information |
| Office: |
Ross Hall, Rm 441 A |
| Lab: |
Ross Hall, Rm 441, 415 |
| Tel: |
(202) 994-2301
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| Fax: |
(202) 994-2488 |
| E-mail: |
phyamk@gwumc.edu |
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Research Interests
Nitric oxide and oxidative stress in septic shock
Nitric oxide, nitrosothiols and reactive oxygen species in macrophage activation
Free radical detection by Electron Paramagnetic Resonance (EPR) spectroscopy
Biomedical applications of EPR (ESR) spectroscopy and spin trapping
Mechanism(s) of zidovudine and iron toxicity in vivo and in vitro
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Selected Publications:
- Komarov, A.M. Commentary on ˇ°Reduction of hexavalent chromium by human cytochrome b 5: Generation of hydroxyl radical and superoxideˇ±. Free Radical Biol. & Med., 42:735-737, 2007.
- Komarov, A.M., Hall, J.M., Chmielinska, J.J., Weglicki, W.B. Iron uptake and release by macrophages is sensitive to propranolol. Mol. Cell. Biochem., 288:213-217, 2006.
- Komarov, A.M., Hall, J.M., Weglicki, W.B. Azidothymidine (AZT) promotes free radical generation by activated macrophages and hydrogen peroxide-iron mediated oxidation in a cell-free system. Biochim. Biophys. Acta 1688: 257-264, 2004.
- Komarov, A.M. Chemistry and biology of nitric oxide. In: Biological Magnetic Resonance, Kluwer, 2003, 18, 325-379.
- Komarov, A.M., Reif, A., Schmidt, H.H.H.W. In vitro detection of nitric oxide and nitroxyl by EPR. Meth. Enzymol. (Nitric Oxide, part D) 359: 18-27, 2002.
- Komarov, A.M. EPR studies of nitric oxide distribution in living mice. Meth. Enzymol. (Nitric Oxide, partD) 359: 66-74, 2002.
- Komarov, A.M. In vivo detection of nitric oxide distribution in mice. Mol. Cell. Biochem. 234/235: 387-392, 2002.
- Komarov, A.M. In vivo on-line detection of NO distribution in endotoxin-treated mice by L-band ESR. Cell. Mol. Biol. 46(8), 1329-1336, 2000.
- Komarov, A.M., Wink, D.A., Feelisch, M., Schmidt, H.H.H.W. Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate cannot discriminate between nitric oxide and nitroxyl: Implications for the detection of reaction products for nitric oxide synthase. Free Radical Biol. Med. 28(5): 739-742, 2000.
- Komarov, A.M., Mak, I.T., Weglicki, W.B. The origin of dinitrosyl-iron complex in endothelial cells. Ann. N.Y. Acad. Sci. 899: 407-410, 2000.
- Komarov, A.M., Reddy, M.N. Effect of septic shock on nitrate, free amino acids and urea in murine plasma and urine. Clin. Biochem. 31(2): 107-111, 1998.
- Komarov, A.M., Mattson, D.L., Mak, I.T., Weglicki, W.B. Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice. FEBS Letters, 424: 253-256, 1998.
- Komarov, A.M., Mak, I.T., Weglicki, W.B. Iron potentiates nitric oxide scavenging by dithiocarbamates in tissue of septic shock mice. Biochim. Biophys. Acta 1361: 229-234, 1997.
- Mak, I.T., Komarov, A.M., Wagner, T., Stafford, R., Dickens, B.F., Weglicki, W.B. Enhanced nitric oxide production during Mg-deficiency and its role in mediating red cell glutathione loss. Am. J. Physiol. 271: C385-390, 1996.
- Komarov, A.M., Joseph, J., Lai, C.-S. In vivo pharmacokinetics of nitroxides in mice. Biochem. Biophys. Research Communications 201(2): 1035-1042, 1994.
- Komarov, A., Mattson, D., Jones, M.M., Singh, P.K., Lai, C.-S. In vivo spin-trapping of nitric oxide in mice. Biochem. Biophys. Research Communications 195(3): 1191-1198, 1993.
- Zhdanov , R.I. , Komarov, A.M., Kayushin, L.P. Aminoxyl spin labels in clinical analysis. In: Bioactive Spin Labels ( Zhdanov, R.I., ed.) New York: Springer, 1992, 585-610.
- Dobryakov, S.N., Komarov, A.M., Kayushin, L.P. Computer-assisted analysis of spin labels spectra in the study of biological membranes. Biofizika 32(5):845-858, 1987.
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