Research Interests

• Chemical and biological properties of the thymosins
• Study of the endocrine role of the thymus gland in relation to aging processes
• Mechanism of action of thymic hormones, cytokines, and other biological response modifiers
• β-thymosins in actin-sequestration and treatment of diseases associated with actin toxicities
• Thymosin β4 in wound healing and angiogenesis
• Role of thymosin β4 in septic shock

Selected Publications (Total of 430 publications):

1. Goldstein, A.L. and Garaci E. (eds) 2007. Thymosins in Health and Disease. New York Academy of Sciences, 1112 (In Press).
2. Goldstein, A.L. 2007. The History of the Development of the Thymosins. New York Academy of Sciences, 1112 (In Press)
3. Bai, X., Wu, J., Zhang, Q., Alesci, S., Manoli, I., Blackman, M. Goldstein, A.L., Rennert, O.M., Su, Y.A. 2007. The Third-Generation Human Mitochondria-focused cDNA Microarray (hMitChip3) and its Bioinformatics for Analysis of Gene Expression. Biotechniques. 42: 365-375.
4. Rubin, B.K., Kater, A.P., Goldstein, A.L. 2006. Thymosin β4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro. Chest, 130:1433-40.
5. Goldstein, A.L., Hannappel, E., and Keinman, H.K. 2005. Thymosin β4: Actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine, 11:421-429.
6. Palmer, D. C., Balasubramaniam, S., Hanada, K., Wrzesinski, C.Y., Zhiya, Y., Farid, S., Theoret, M.R., Hwang, L.N., Klebanoff, C.A., Gattinoni, L., Goldstein, A.L., Yang, J.C., and Restifo, N.P. 2004. Vaccine-Stimulated, Adoptively Transferred CD+8 T Cells Traffic Indiscriminately and Ubiquitously while Mediating Specific Tumor Destruction. The Journal of Immunology, 173:7209-7216.
7. Makogonenko, E., Goldstein, A.L., Bishop, P.D., Medved, L. 2004. Factor XIII32 a Incorporates Thymosin β4 Preferentially into the Fibrin (ogen) aC-Domains. Biochemistry, 43:10748-10756.
8. Philp, D., Goldstein, A.L., Kleinman, H.K. 2004. Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development. Mech. Aging and Develop.; 125:113-115.
9. Goldstein, A.L. Thymosin b 4: 2003. A New Molecular Target for Antitumor Strategies. Journal of the National Cancer Institute; 95:1646-1647.
10. Badamchian, M., Fagarasan, M.O., Danner, R.L., Suffredini, A.F., Damavandy, H., Goldstein, A.L. 2003; Thymosin β4 reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock. International Immunopharmacology; 3:1225-1233.