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Sidney W. Fu
Associate Research Professor Director, Genomics Core Facility
Cancer Genetics, Functional Genomics and Bioinformatics |
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Contact Information |
| Office: |
Ross Hall, Rm 536 |
| Lab: |
Ross Hall, Rm 520 |
| Tel: |
(202) 994-4767
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| Fax: |
(202) 994-2487 |
| E-mail: |
sfu@gwu.edu |
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Research Interests
Cell cycle regulation by homeobox transcriptional factors.
Roles for BP1, HOXB7 homeobox gene in proliferation, differentiation, and tumorigenesis.
Potential diagnostic and prognostic molecular markers in breast cancer.
Biomarkers for Type II diabetes.
Functional genomics and bioinformatics.
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Selected Publications:
- Kehn K, Berro R, Alhaj A, Bottazzi ME, Yeh W-I, Klase Z, Van Duyne R, Fu S and Kashanchi F. Functional consequences of cyclin consequences of cyclin D1/BRCA1 interaction in breast cancer cells. Oncogene. 2007 [Epub]
- Brody F, Hill S, Celenski S, Kar R, Kluk B, Pinzone J and Fu S. Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients. Surg Endosc. 2007 [Epub].
- Xian YS, Dang CX, Yan CX, Li HP, Fu SW, Wang ZR. Clinicopathological significance of homeobox BP1 mRNA expression in lung cancer tissue. Nan Fang Yi Ke Da Xue Xue Bao., 26(8):1173-5, 2006.
- Fu, SW. Identification of cancer biomarkers using DNA microarrays. Pharmaceutical Discovery 5(7): Supplement (The State of the Art in Microarray Technology for Biomarker Discovery). 18-21, 2005.
- Cahan, P., Ahmad, A., Burke, H., Fu, S., Lai, Y., Florea, L., Dharker, N., Kobrinski, T., Kale, P. and McCaffrey, T. List of Lists-Annotated (LOLA): A database for annotation comparison of published microarray gene lists. Gene, 360(1):78-82, 2005.
- Man Y-G, Fu SW, Schwartz A, Pinzone JJ, Simmens, SJ, Berg PE. Expression of BP1, a novel homobox gene, correlates with breast cancer progression and invasion. Breast Cancer Research and Treatment. 90:241-247, 2005.
- Fu SW, Schwartz A, Stevenson H, Pinzone JJ, Davenport GJ, Orenstein JM, Gutierrez P, Simmens SJ, Abraham J, Poola I, Stephan DA, Berg PE. Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Breast Cancer Research 5:82-87, 2003.
- Fu S*, Chase MB, Haga SB, Davenport G, Stevenson H, Do K, Morgan D, Mah AL, Berg PE. BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. Molecular and Cellular Biology. 22:2505-14, 2002 (*Co-first author with Chase MB).
- Fu S, Stevenson H, Strovel JW, Haga SB, Stamberg J, Do K, Berg PE. Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. Gene. 278:131-9, 2001.
- Haga SB, Fu S, Karp JE, Ross DD, Hankins WD, Williams DM, Behm F, Ruscetti FW, Chang M, Smith BD, Becton D, Raimondi SC, Berg PE. BP1, a new homeobox gene, is frequently expressed in acute leukemias. Leukemia. 14: 1867-1875, 2000.
- Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med. 29(9): 881-8. 2000.
- Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, Wilson KT. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. American Journal of Physiology. 275(3 Pt 1):G592-603, 1998.
- Wilson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression and localization of inducible nitric oxide synthase and cyclooxygenase 2 in Barrett's Esophagus and associated adenocarcinomas. Cancer Research. 58: 2929-2934, 1998.
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