Research Interests

1. Aging
2. Isolation and chemical characterization of novel peptides from thymus that inhibits:
   1. Human prostate and breast cancer cell proliferation.
   2. Brain tumor cell growth.
   3. Human melanoma tumor cell proliferation.
   4. Human leukemia (HL-60) cell proliferation.
3. Mucolytic characterization of actin sequestering peptides in Cystic Fibrosis.
4. The thymus-skin connection: Immunology of aging and wound healing.
5. Isolation and chemical characterization of molecules from barley leaf extract that has 1) anti-tumor activity and 2) Inhibits human platelets aggregation.
6. The thymus-septic shock connection: Thymosin ß4 Reduces Lethality and Down Regulates Inflammatory Mediators in Endotoxin-Induced Septic Shock

Selected Publications:

1. Moody, T.W., Leyton, J., Zia, F., Tuthill, C., Badamchian, M., Goldstein, A.L. "Thymosin alpha 1 is chemopreventive for lung adenoma formation in A/J mice." (2000) Cancer Letters, 155:121-127.
2. Baumann,C.A., Badamchian,M., and Goldstein, A.L., "Thymosin alpha1 is a time and dose-dependent antagonist of dexamethasone-induced apoptosis of murine thymocytes in vitro." (2000) Int. J. Immunopharmacology, 22(10), 1057-66.
3. Pompilius, M., Farrimound, D.D., Jarvis, W.D., Badamchian, M., Goldstein, AL., Spangelo, B.L., "Anti-proliferative action of thymic hormones on HL-60 human promyelocytic leukemia cells." (2000) The Endocrine Society, P. 189.
4. Zhan, B., Badamchian, M., Meihua, B., Ashcom, J., Howdon, J., Shuhua, X., and Hotez, P. "Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookoworms" (2002) Am. J. Med. Hyg., 66(3) 238-244
5. Philip, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A.L., and Kleinman, H.K., "Thymosin beta 4 and a synthetic peptide containing its actin binding domain promote dermal wound repair in db/db diabetic mice and aged mice." (2003) Wound Repair and Regeneration. 11(1)19-24.
6. Badamchian, M., Fagarasan, M.O., Danner, R.L., Stuffredini, A.F., Damavandy,H., and Goldstein, A.L. "Thymosin beta 4 reduces lethality and down regulates inflammatory mediators in endotoxin-induced septic shock."(2003) International Immunopharmacology. 3, 1225-1233
7. Goldstein, A.L., and Badamchian, M., "The endocrine thymus: Chemistry, biology, and clinical application of thymosin peptides." Book chaper in preparation
8. Badamchian,M., Damavandy,T., Kater, A.P., Fink, R.F., and Goldstein, A.L., "Thymosin beta 4 plays a key role in the regulation of actin polymerization and depolymerization: Development of an analytical methodology to study the properties of actin in cystic fibrosis sputum in vitro." J. Chromatography. Jan-Feb;11(1):19-24.
9. Goldstein, A.L., and Badamchian, M. "Thymosins: Chemistry and biological properties in health and disease"(2004) Expert Opinion Biol. ther. 4(4).
10. Spangelo BL, Pompilius M, Farrimond DD, Stevens N, Nieva R, Shroff S, Badamchian M, Johnson CR, Jarvis WD., "Presence of a peptide component of thymosin fraction-5 manifesting discrete cytostatic properties in HL-60 human promyelocytic leukemia cells."(2005) Int. Immuno. Pharm. 5, 1317-1329.