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Description of Core Courses
- Bioc 221 (4) and 222 (4) - General Biochemistry:
A two course sequence that provides
students with a fundamental understanding of the chemical structures
and functions of the components of living matter as well as the
metabolic reactions that
occur in living cells. This information is essential to the study
of genomics, proteomics, and bioinformatics as well as disciplines
such as genetics, molecular biology, oncology, and pharmacology.
- Bioc 234 (3) - Structure and Function of Proteins
and Enzymes:
Structure-Function relationships of
proteins, enzyme kinetics, regulation and reaction mechanisms. This course is a complement
to the Bioc 236 and 237, especially its proteomics aspect.
- Bioc 235 (1) - Genomics, Proteomics, and Bioinformatics
Seminar:
These seminars are scheduled once every
two weeks and will be a combination of research presentations
by faculty, and/or guests from outside. There will also be journal
club presentations by students of high quality papers. These seminars
will run for the entire two years.
- Bioc 236 (2) and 237 (2) - Fundamentals of
Genomics, and Proteomics:
These courses will cover fundamentals of Genomics
and Proteomics. Specifically, linkage and SNP analyses (DHPLC,
microsequencing, 3rd wave), statistical and computational
aspects of linkage and association, as well as automated
sequencing, high throughput fluidics, genomics database
resources and use will be covered. Topics in expression profiling including Affymetrix
chip arrays, and spotted cDNA and oligonucleotide arrays as well
as manipulation of large data sets in expression profiling will
be discussed.
The Proteomics component will focus also on the history
of proteomics as well as the latest developments in the field
of protein research. Proteomics is the large-scale study of proteins,
their partners and post-translation modification such as phosphorlyation,
glycosylation, sulphation as well as other modifications that
can determine activity, stability, localization and turnover protein
function. These modifications are not generally apparent from
genomic sequence or mRNA expression data.
- Bioc 254 (3) - Fundamentals of Molecular Biology:
Fundamentals of molecular
biology, DNA, RNA, and protein interactions, and their
regulation in relation to eukaryotic cells.
- CSci 144 (3) - Introduction to Bioinformatics
This course will provide a broad introduciton
to the area of bioinformatics. Topics include: biochemistry overview,
databases, the alignment problem, proteins and protein structure-function,
introductory phylogenetics, and use of public databases.
More information is available at the course
website: http://www.seas.gwu.edu/~simhaweb/cs177
For more information, visit the George Washington
University Bulletin or see individual departmental websites.
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